CQ8. What Are the Sensitivity and Specificity of Aspiration Cytology?

  • Shinichi Suzuki
  • Nobuhiro Fukunari
  • Kaori Kameyama
  • Megumi Miyakawa
  • Katsuhiro Tanaka
  • Yatsuka Hibi


Over 20 years have passed since the development of FNA, and because of its low cost and low complications it has become an indispensable procedure in the arsenal of thyroid tumor diagnosis. The earliest reports of the utility of cytology date back to the 1970s. It was eventually replaced by the echo-guided FNA that we have today and further improvements in predictive value and early detection of cancer are still being sought. This section evaluates data published since 2000.


Thyroid Cancer False Negative False Positive Rate False Negative Rate Papillary Carcinoma 
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  1. 1.
    Haberal AN, Toru S, Ozen O et al (2009) Diagnostic pitfalls in the evaluation of fine needle aspiration cytology of the thyroid: correlation with histopathology in 260 cases. Cytopathology 20:103–108 (RCT)PubMedCrossRefGoogle Scholar
  2. 2.
    Amrikachi M, Ramzy I, Rubenfeld S et al (2001) Accuracy of fine-needle aspiration of thyroid. Arch Pathol Lab Med 125:484–488 (RCT)PubMedGoogle Scholar
  3. 3.
    Sangalli G, Serio G, Zampatti C et al (2006) Fine needle aspiration cytology of the thyroid: a comparison of 5469 cytological and final histological diagnosis. Cytopathology 17:245–250 (RCT)PubMedCrossRefGoogle Scholar
  4. 4.
    Yang J, Schnadig V, Logrono R et al (2007) Fine-needle aspiration of thyroid nodules: a study of 4703 patients with histologic and clinical correlations. Cancer 11:306–315 (RCT)CrossRefGoogle Scholar
  5. 5.
    Furlan JC, Bedard YC, Rosen IB (2005) Single versus sequential fine-needle aspiration biopsy in the management of thyroid nodular disease. Can J Surg 48:12–18 (RCT)PubMedGoogle Scholar
  6. 6.
    Amrikachi M, Ponder TB, Wheeler TM et al (2005) Thyroid fine-needle aspiration biopsy in children and adolescents: experience with 218 aspirates. Diagn Cytopathol 32:189–192 (RCT)PubMedCrossRefGoogle Scholar
  7. 7.
    Papanicolaou society of cytopathology recommendations for thyroid fine needle aspiration. http://www.papsociety.org/guidelines.html. Accessed 27 Jul 2007 (Others)
  8. 8.
    General Rules for the Description of Thyroid Cancer, 6th Edition (Text in Japanese), Kanehara Publishing, 2005 (Others)Google Scholar
  9. 9.
    Bakhos R, Selvaggi SM, Dejong S et al (2000) Fine-needle aspiration of the thyroid: rate and causes of cytohistopathologic discordance. Diagn Cytopathol 23:233–237 (RCT)PubMedCrossRefGoogle Scholar
  10. 10.
    Ylagan LR, Farkas T, Dehner LP (2004) Fine-needle aspiration of the thyroid: a cytohistologic correlation and study of discrepant cases. Thyroid 14:35–41 (RCT)PubMedCrossRefGoogle Scholar
  11. 11.
    Blansfield JA, Sack MJ, Kukora JS (2002) Recent experience with preoperative fine-needle aspiration biopsy of thyroid nodules in a community hospital. Arch Surg 137:818–821 (RCT)PubMedCrossRefGoogle Scholar
  12. 12.
    Sclabes GM, Staekel GA, Shapiro SE et al (2003) Fine-needle aspiration of the thyroid and correlation with histopathology in a contemporary series of 240 patients. Am J Surg 186:702–710CrossRefGoogle Scholar
  13. 13.
    Mittendorf EA, Tamarkin SW, McHenry CR (2002) The results of ultrasound-guided fine-needle aspiration biopsy for evaluation of nodular thyroid disease. Surgery 132:648–654PubMedCrossRefGoogle Scholar
  14. 14.
    Ravetto C, Colombo L, Dottorini ME (2000) Usefulness of fine-needle aspiration in the diagnosis of thyroid carcinoma: a retrospective study in 37,895 patients. Cancer Cytopathol 90:357–363 (RCT)Google Scholar

Copyright information

© Springer Japan 2013

Authors and Affiliations

  • Shinichi Suzuki
    • 1
  • Nobuhiro Fukunari
    • 2
  • Kaori Kameyama
    • 3
  • Megumi Miyakawa
    • 4
  • Katsuhiro Tanaka
    • 5
  • Yatsuka Hibi
    • 6
  1. 1.Department of Organ Regulation SurgeryFukushima Medical University, School of MedicineFukushimaJapan
  2. 2.Department of SurgeryShowa University Northern Yokohama HospitalYokohamaJapan
  3. 3.Department of Diagnostic PathologyKeio University School of MedicineTokyoJapan
  4. 4.Endocrine CenterToranomon HospitalTokyoJapan
  5. 5.Department of Breast and Thyroid SurgeryKawasaki Medical SchoolKurashikiJapan
  6. 6.Department of Endocrine SurgeryFujita Health University School of MedicineToyoakeJapan

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