Advertisement

Conclusions

  • Shinsuke Inuki
Chapter
Part of the Springer Theses book series (Springer Theses)

Abstract

Total synthesis of pachastrissamine (jaspine B) through a novel palladium(0)-catalyzed bis-cyclization of bromoallenes bearing hydroxyl and benzamide groups as internal nucleophiles was achieved. The key feature of this synthetic route is the late-stage introduction of the long alkyl side chain into the tetrahydrofuran ring at the C-2 position. Pachastrissamine derivatives with various alkyl groups were produced using different alkylation reagents.

Keywords

Synthetic Route Ergot Alkaloid Total Synthesis Aryl Halide Alkyl Side Chain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer 2012

Authors and Affiliations

  1. 1.Graduate School of Pharmaceutical SciencesKyoto UniversityKyotoJapan

Personalised recommendations