Abstract
Total synthesis of pachastrissamine (jaspine B) through a novel palladium(0)-catalyzed bis-cyclization of bromoallenes bearing hydroxyl and benzamide groups as internal nucleophiles was achieved. The key feature of this synthetic route is the late-stage introduction of the long alkyl side chain into the tetrahydrofuran ring at the C-2 position. Pachastrissamine derivatives with various alkyl groups were produced using different alkylation reagents.
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© 2012 Springer
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Inuki, S. (2012). Conclusions. In: Total Synthesis of Bioactive Natural Products by Palladium-Catalyzed Domino Cyclization of Allenes and Related Compounds. Springer Theses. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54043-4_6
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DOI: https://doi.org/10.1007/978-4-431-54043-4_6
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Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-54042-7
Online ISBN: 978-4-431-54043-4
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