• Shinsuke Inuki
Part of the Springer Theses book series (Springer Theses)


Total synthesis of pachastrissamine (jaspine B) through a novel palladium(0)-catalyzed bis-cyclization of bromoallenes bearing hydroxyl and benzamide groups as internal nucleophiles was achieved. The key feature of this synthetic route is the late-stage introduction of the long alkyl side chain into the tetrahydrofuran ring at the C-2 position. Pachastrissamine derivatives with various alkyl groups were produced using different alkylation reagents.


Synthetic Route Ergot Alkaloid Total Synthesis Aryl Halide Alkyl Side Chain 
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Copyright information

© Springer 2012

Authors and Affiliations

  1. 1.Graduate School of Pharmaceutical SciencesKyoto UniversityKyotoJapan

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