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Palladium-Catalyzed Domino Cyclization of Amino Allenes Bearing a Bromoindolyl Group and Its Application to Total Synthesis of Ergot Alkaloids

  • Shinsuke Inuki
Chapter
Part of the Springer Theses book series (Springer Theses)

Abstract

Ergot alkaloids and their synthetic analogs have been reported to exhibit broad biological activity. The author investigated direct construction of the C/D ring system of ergot alkaloids based on palladium-catalyzed domino cyclization of amino allenes. With this biscyclization as the key step, total synthesis of (±)-lysergic acid, (±)-lysergol and (±)-isolysergol was achieved.

Keywords

Ergot Alkaloid Flash Chromatography Oily Residue Saturated NaHCO3 Lysergic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer 2012

Authors and Affiliations

  1. 1.Graduate School of Pharmaceutical SciencesKyoto UniversityKyotoJapan

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