Search for New Medicinal Seeds from Marine Organisms

  • Motomasa Kobayashi
  • Naoyuki Kotoku
  • Masayoshi Arai
Conference paper


Tumor tissue is composed of cancer cells, extracellular matrix molecules, and several host-derived cells such as endothelial cells, fibroblast cells, and immune cells. Tumor microenvironments are constructed of interactions between these cells and molecules. In addition, it has become clear that the tumor microenvironment plays an important role in tumor progression. Therefore, the microenvironments in tumor tissue are considered to be attractive targets for cancer chemotherapy. Especially, angiogenesis and hypoxia-adapted cancer cells have attracted much attention as new drug targets.


Vascular Endothelial Growth Factor DU145 Cell Selective Index Normal Human Dermal Fibroblast Steroidal Alkaloid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



We thank all members of our laboratory for their assistance. This work was supported by the Grant-in-Aid for Scientific research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, and the Uehara Memorial Foundation.


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Copyright information

© Springer 2012

Authors and Affiliations

  • Motomasa Kobayashi
    • 1
  • Naoyuki Kotoku
    • 1
  • Masayoshi Arai
    • 1
  1. 1.Graduate School of Pharmaceutical SciencesOsaka UniversitySuita, OsakaJapan

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