Search for New Medicinal Seeds from Marine Organisms
Tumor tissue is composed of cancer cells, extracellular matrix molecules, and several host-derived cells such as endothelial cells, fibroblast cells, and immune cells. Tumor microenvironments are constructed of interactions between these cells and molecules. In addition, it has become clear that the tumor microenvironment plays an important role in tumor progression. Therefore, the microenvironments in tumor tissue are considered to be attractive targets for cancer chemotherapy. Especially, angiogenesis and hypoxia-adapted cancer cells have attracted much attention as new drug targets.
KeywordsVascular Endothelial Growth Factor DU145 Cell Selective Index Normal Human Dermal Fibroblast Steroidal Alkaloid
We thank all members of our laboratory for their assistance. This work was supported by the Grant-in-Aid for Scientific research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, and the Uehara Memorial Foundation.
- 2.Aoki S, Cho SH, Ono M, Kuwano T, Nakao S, Kuwano M, Nakagawa S, Gao JQ, Mayumi T, Shibuya M, Kobayashi M (2006) Bastadin 6, a spongean brominated tyrosine derivative, inhibits tumor angiogenesis by inducing selective apoptosis to endothelial cells. Anticancer Drugs 17:269–278PubMedCrossRefGoogle Scholar