An Approach Toward Identification of Target Proteins of Maitotoxin Based on Organic Synthesis
Maitotoxin (MTX) is the principal toxin of ciguatera, a common form of seafood poisoning caused by consumption of fish from subtropical and tropical regions that carry the epiphytic dinoflagellate Gambierdiscus toxicus. Ciguatera is characterized by gastrointestinal, cardiovascular, and neurological disorders, and affects more than 50,000 people annually. MTX is produced by G. toxicusliving on macroalgae, and the toxin accumulates in fish as a result of transfer through the food chain . Although limited supplies of MTX from natural sources have hampered efforts to determine its molecular structure, the Yasumoto and Murata group ultimately elucidated the structure through extensive nuclear magnetic resonance (NMR) analysis [2, 3], and the complete stereochemistry of MTX was determined by the Kishi and Tachibana groups (Fig. 1) [4–7].
KeywordsNuclear Magnetic Resonance Ring System Hemolytic Activity Cyclic Ether Benzyl Ether
This work was supported by The Uehara Memorial Foundation, a Grant-in-Aid for Scientific Research (B) (No. 21350028) from JSPS, and a Grant-in-Aid for Scientific Research on Innovative Areas (No. 22106530) from MEXT.
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