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An Approach Toward Identification of Target Proteins of Maitotoxin Based on Organic Synthesis

  • Tohru Oishi
  • Keiichi Konoki
  • Rie Tamate
  • Kohei Torikai
  • Futoshi Hasegawa
  • Takeharu Nakashima
  • Nobuaki Matsumori
  • Michio Murata
Conference paper

Abstract

Maitotoxin (MTX) is the principal toxin of ciguatera, a common form of seafood poisoning caused by consumption of fish from subtropical and tropical regions that carry the epiphytic dinoflagellate Gambierdiscus toxicus. Ciguatera is characterized by gastrointestinal, cardiovascular, and neurological disorders, and affects more than 50,000 people annually. MTX is produced by G. toxicusliving on macroalgae, and the toxin accumulates in fish as a result of transfer through the food chain [1]. Although limited supplies of MTX from natural sources have hampered efforts to determine its molecular structure, the Yasumoto and Murata group ultimately elucidated the structure through extensive nuclear magnetic resonance (NMR) analysis [2, 3], and the complete stereochemistry of MTX was determined by the Kishi and Tachibana groups (Fig. 1) [4–7].

Keywords

Nuclear Magnetic Resonance Ring System Hemolytic Activity Cyclic Ether Benzyl Ether 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

This work was supported by The Uehara Memorial Foundation, a Grant-in-Aid for Scientific Research (B) (No. 21350028) from JSPS, and a Grant-in-Aid for Scientific Research on Innovative Areas (No. 22106530) from MEXT.

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Copyright information

© Springer 2012

Authors and Affiliations

  • Tohru Oishi
    • 1
  • Keiichi Konoki
    • 2
  • Rie Tamate
    • 3
  • Kohei Torikai
    • 1
  • Futoshi Hasegawa
    • 3
  • Takeharu Nakashima
    • 3
  • Nobuaki Matsumori
    • 3
  • Michio Murata
    • 3
  1. 1.Department of Chemistry, Faculty and Graduate School of SciencesKyushu UniversityFukuokaJapan
  2. 2.Graduate School of Agricultural ScienceTohoku UniversitySendaiJapan
  3. 3.Department of Chemistry, Graduate School of ScienceOsaka UniversityToyonakaJapan

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