Enzymes as Chemotherapeutic Agents

Conference paper


Typical chemotherapeutic agents act by disrupting the flow of biochemical information (Fig. 1). The most common strategy uses small organic molecules to inhibit the function of a protein. Information flow can be disrupted at earlier stages. For example, an antisense oligonucleotide (Vitravene; Isis Pharmaceuticals) acts at the RNA level to treat eye infections caused by cytomegalovirus.


Ribonuclease Inhibitor Lysosomal Storage Disease Biochemical Information Northern Leopard Frog Ribonucleolytic Activity 



I am grateful to the graduate students and postdoctorates who have worked with me on the development of ribonucleases as chemotherapeutic agents. Their names dominate the list of references. Our work has been supported by grants R01 CA073808 from the NIH and 51670 from the Bill & Melinda Gates Foundation.


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Copyright information

© Springer 2012

Authors and Affiliations

  1. 1.Department of BiochemistryUniversity of Wisconsin-MadisonMadisonUSA

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