Nongenomic Mechanism-Mediated Renal Fibrosis-Decreasing Activity of a Series of PPAR-γ Agonists

  • Hiroyuki Miyachi
Conference paper


The number of dialysis patients with chronic kidney disease (CKD) is gradually increasing, especially in Westernized countries. Renal fibrosis is a basic risk factor for CKD, and CKD in turn is considered to be an independent risk factor for cardiovascular disease. CKD is defined as a progressive loss of function over a long period of time. It affects patients worldwide and is associated with a high morbidity and mortality rate. CKD affects more than 13% of the population in the United States (USA) [1] and in Europe [2].


Chronic Kidney Disease Renal Fibrosis Alkoxyl Group Estrogen Receptor Agonist Phenylpropanoic Acid 
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Copyright information

© Springer 2012

Authors and Affiliations

  1. 1.Graduate School of Medicine, Dentistry and Pharmaceutical SciencesOkayama UniversityOkayamaJapan

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