Chemical Approaches for Understanding and Controlling Infectious Diseases
Vancomycin and its related glycopeptide antibiotics are known for their therapeutic importance against methicillin-resistant Staphylococcus aureus(MRSA). Unfortunately, vancomycin-resistant enterococci (VRE) have emerged as an important nosocomial pathogen worldwide, and recently vancomycin-resistant Staphylococcus aureus(VRSA) acquired the vanA-resistant gene from VRE.
KeywordsCell Wall Synthesis Peptidoglycan Biosynthesis Cross Metathesis Lipid Intermediate Cell Wall Precursor
The author is grateful to collaborators in Tohoku University and Shionogi & Co., Ltd., whose names appear in the references, for their hard work, creativity, and superb research skills. This work was supported in part by Grants-in-Aid for Scientific Research from MEXT, Japan (Nos. 17035039, 18032010, and 21310136) and by funds from the Uehara Memorial Foundation.
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