Establishment of a Novel System for Studying the Syk Function in B Cells

  • Tomohiro Kurosaki
  • Clifford A. Lowell
Conference paper


The signal through the B-cell antigen-receptor (BCR) complex, which is composed of the BCR itself and the Igα (CD79a)/Igβ (CD79b) heterodimer, is essential for B-cell development and humoral immune responses. The cytoplasmic domains of both Igα and Igβ have an ITAM (immunoreceptor tyrosine-based activation motif), and tyrosine residues in the ITAM are phosphorylated after BCR stimulation followed by the recruitment and activation of protein tyrosine kinases (PTKs). Two classes of the BCR-associated PTK are now defined: Src-PTK such as Lyn, Fyn, Blk, Lck [1–3], and spleen tyrosine kinase, Syk.


Tyrosine Phosphorylation Mutant Kinase Spleen Tyrosine Kinase Small Molecule Kinase Inhibitor Porcine Spleen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer 2012

Authors and Affiliations

  1. 1.Laboratory for Lymphocyte Differentiation, WPI Immunology Frontier Research CenterOsaka UniversityOsakaJapan
  2. 2.RIKEN Research Center for Allergy and ImmunologyKanagawaJapan
  3. 3.Department of Laboratory MedicineUniversity of CaliforniaSan FranciscoUSA

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