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Cell-Surface Glycoconjugates Controlling Human T-Lymphocyte Homing: Implications for Bronchial Asthma and Atopic Dermatitis

  • Reiji Kannagi
  • Keiichiro Sakuma
  • Katsuyuki Ohmori
Conference paper

Abstract

Cell-surface glycans play important roles in lymphocyte traffic and homing. Cell adhesion mediated by glycans, such as selectin-mediated cell adhesion, is involved in the first step of every process of extravasation of leukocytes, either in granulocytes or in lymphocytes (Fig. 1). Glycan-mediated cell adhesion is virtually an only one cell-adhesion system that tolerates a strong shear force of normal blood flow in the general circulation. This step is crucial for every leukocyte diapedesis; without glycan-mediated cell adhesion, other secondary proteinaceous cell-adhesion molecules such as integrins or the Ig superfamily do not operate effectively. Recently, it has become increasingly clear that homing processes of various subsets of T lymphocytes are elegantly regulated by different species of cell-adhesive glycans, and alterations in glycan expression are closely associated with the pathophysiology of several well-known human diseases.

Keywords

Atopic Dermatitis Sialic Acid Peripheral Lymph Node High Endothelial Venule Selectin Ligand 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

This work was supported in part by grants-in-aid from the Ministry of Education, Culture, Sports, Science and Technology (24590364 and on innovative areas 23112520), grants-in-aid for young scientists from the Japan Society for the Promotion of Science (20790583 and 22790774), grants-in-aid for the Third-Term Comprehensive Ten-year Strategy for Cancer Control from the Ministry of Health and Welfare, and a grant from the Uehara Memorial Foundation, Japan.

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Copyright information

© Springer 2012

Authors and Affiliations

  • Reiji Kannagi
    • 1
    • 2
  • Keiichiro Sakuma
    • 1
    • 2
  • Katsuyuki Ohmori
    • 3
  1. 1.Research Complex for Medical FrontiersAichi Medical UniversityNagakute, AichiJapan
  2. 2.Department of Molecular PathologyAichi Cancer CenterNagoyaJapan
  3. 3.Department of Clinical PathologyKyoto University School of MedicineKyotoJapan

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