Abstract
Cell-surface glycans play important roles in lymphocyte traffic and homing. Cell adhesion mediated by glycans, such as selectin-mediated cell adhesion, is involved in the first step of every process of extravasation of leukocytes, either in granulocytes or in lymphocytes (Fig. 1). Glycan-mediated cell adhesion is virtually an only one cell-adhesion system that tolerates a strong shear force of normal blood flow in the general circulation. This step is crucial for every leukocyte diapedesis; without glycan-mediated cell adhesion, other secondary proteinaceous cell-adhesion molecules such as integrins or the Ig superfamily do not operate effectively. Recently, it has become increasingly clear that homing processes of various subsets of T lymphocytes are elegantly regulated by different species of cell-adhesive glycans, and alterations in glycan expression are closely associated with the pathophysiology of several well-known human diseases.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Lowe JB, Stoolman LM, Nair RP, Larsen RD, Berhend TL, Marks RM (1990) ELAM-1-dependent cell adhesion to vascular endothelium determined by a transfected human fucosyltransferase cDNA. Cell 63:475–484
Phillips ML, Nudelman E, Gaeta FCA, Perez M, Singhal AK, Hakomori S, Paulson JC (1990) ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex. Science 250:1130–1132
Walz G, Aruffo A, Kolanus W, Bevilacqua M, Seed B (1990) Recognition by ELAM-1 of the sialyl-Lexdeterminant on myeloid and tumor cells. Science 250:1132–1135
Mitsuoka C, Sawada-Kasugai M, Ando-Furui K, Izawa M, Nakanishi H, Nakamura S, Ishida H, Kiso M, Kannagi R (1998) Identification of a major carbohydrate capping group of the L-selectin ligand on high endothelial venules in human lymph nodes as 6-sulfo sialyl Lewis x. J Biol Chem 273:11225–11233
Kimura N, Mitsuoka C, Kanamori A, Hiraiwa N, Uchimura K, Muramatsu T, Tamatani T, Kansas GS, Kannagi R (1999) Reconstitution of functional L-selectin ligands on a cultured human endothelial cell line by co-transfection of α1 → 3 fucosyltransferase VII and newly cloned GlcNAcβ 6-sulfotransferase cDNA. Proc Natl Acad Sci USA 96:4530–4535
Ohmori K, Fukui F, Kiso M, Imai T, Yoshie O, Hasegawa H, Matsushima K, Kannagi R (2006) Identification of cutaneous lymphocyte-associated antigen as sialyl 6-sulfo Lewis x, a selectin ligand expressed on a subset of skin-homing helper memory T cells. Blood 107:3197–3204
Sallusto F, Lanzavecchia A (2009) Heterogeneity of CD4+memory T cells: functional modules for tailored immunity. Eur J Immunol 39:2076–2082
Sallusto F, Baggiolini M (2008) Chemokines and leukocyte traffic. Nat Immunol 9:949–952
Campbell JJ, Clark RA, Watanabe R, Kupper TS (2010) Sezary syndrome and mycosis fungoides arise from distinct T-cell subsets: a biologic rationale for their distinct clinical behaviors. Blood 116:767–771
Santamaria-Babi LF (2006) Skin-homing T cells in cutaneous allergic inflammation. Chem Immunol Allergy 91:87–97
Santamaria-Babi LF (2004) CLA+T cells in cutaneous diseases. Eur J Dermatol 14:13–18
Seneviratne SL, Black AP, Jones L, Bailey AS, Ogg GS (2007) The role of skin-homing T cells in extrinsic atopic dermatitis. Q J Med 100:19–27
Bateman EA, Ardern-Jones MR, Ogg GS (2006) Persistent central memory phenotype of circulating Fel d 1 peptide/DRB1*0101 tetramer-binding CD4+T cells. J Allergy Clin Immunol 118:1350–1356
Kannagi R (2001) Transcriptional regulation of expression of carbohydrate ligands for cell adhesion molecules in the selectin family. Adv Exp Med Biol 491:267–278
Chen G-Y, Osada H, Santamaria-Babi LF, Kannagi R (2006) Interaction of GATA-3/T-bet transcription factors regulates expression of sialyl Lewis X homing receptors on Th1/Th2 lymphocytes. Proc Natl Acad Sci USA 103:16894–16899
Chen G-Y, Sakuma K, Kannagi R (2008) Significance of NF-κB/GATA axis in TNF-α-induced expression of 6-sulfated cell-recognition glycans in human T-lymphocytes. J Biol Chem 283:34563–34570
Sakuma K, Chen GY, Aoki M, Kannagi R (2012) Induction of 6-sulfated glycans with cell adhesion activity via T-bet and GATA-3 in human helper T cells. Biochem Biophys Acta 1820:841–848
Mitsuoka C, Ohmori K, Kimura N, Kanamori A, Komba S, Ishida H, Kiso M, Kannagi R (1999) Regulation of selectin binding activity by cyclization of sialic acid moiety of carbohydrate ligands on human leukocytes. Proc Natl Acad Sci USA 96:1597–1602
Kannagi R (2002) Regulatory roles of carbohydrate ligands for selectins in homing of lymphocytes. Curr Opin Struct Biol 12:599–608
Izawa M, Kumamoto K, Mitsuoka C, Kanamori A, Ohmori K, Ishida H, Nakamura S, Kurata-Miura K, Sasaki K, Nishi T, Kannagi R (2000) Expression of sialyl 6-sulfo Lewis x is inversely correlated with conventional sialyl Lewis x expression in human colorectal cancer. Cancer Res 60:1410–1416
Acknowledgments
This work was supported in part by grants-in-aid from the Ministry of Education, Culture, Sports, Science and Technology (24590364 and on innovative areas 23112520), grants-in-aid for young scientists from the Japan Society for the Promotion of Science (20790583 and 22790774), grants-in-aid for the Third-Term Comprehensive Ten-year Strategy for Cancer Control from the Ministry of Health and Welfare, and a grant from the Uehara Memorial Foundation, Japan.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2012 Springer
About this paper
Cite this paper
Kannagi, R., Sakuma, K., Ohmori, K. (2012). Cell-Surface Glycoconjugates Controlling Human T-Lymphocyte Homing: Implications for Bronchial Asthma and Atopic Dermatitis. In: Shibasaki, M., Iino, M., Osada, H. (eds) Chembiomolecular Science. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54038-0_16
Download citation
DOI: https://doi.org/10.1007/978-4-431-54038-0_16
Published:
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-54037-3
Online ISBN: 978-4-431-54038-0
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)