Prism Adaptation and the Rehabilitation of Spatial Neglect

  • Sophie Jacquin-Ciourtois
  • Jacinta O’Shea
  • Jacques Luauté
  • Laure Pisella
  • Alessandro Farné
  • Patrice Revol
  • Gilles Rode
  • Yves Rossetti


A large proportion of right-hemisphere stroke patients exhibits spatial neglect, a neurological condition characterised by deficits for perceiving, attending, representing, and/or performing actions within their left-sided space. spatial neglect is responsible for many debilitating effects on everyday life, for poor functional recovery, and for decreased ability to benefit from treatment. Prism adaptation (PA) to a right lateral displacement of the visual field (induced by a simple target-pointing task while wearing base-left wedge prisms) is known to directionally bias visuo-motor and sensory-motor correspondences and has recently been found to improve various symptoms of neglect. For example, performance on classical pen-and-pencil visuo-motor tests could be improved for at least 2 h following adaptation. Further effects of PA have also been described for non-motor and non-visual tasks, such as for somatosensory extinction or dichotic listening, for deficits in mental imagery of geographic maps and in number bisection, and even for visuo-constructive disorders. These results suggest that the effects of prism adaptation can extend to unexposed sensory systems. The bottom-up approach of visuo-motor adaptation appears to interact with higher order brain functions related to multisensory integration and can have beneficial effects on sensory processing in different modalities. Lesion studies and functional imaging data point to a cerebello-cortical network in which the cerebellum is crucial for adaptation and the cortex is involved in functional gains. Prism adaptation may act not only on the ipsilesional bias characteristic of neglect and also alleviate more generally other spatial cognition deficits due to attentional bias.


Complex Regional Pain Syndrome Multisensory Integration Neglect Patient Spatial Neglect Visuomotor Adaptation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Brain WR (1941) Visual disorientation with special reference to lesions of the right cerebral hemisphere. Brain 64:244–271CrossRefGoogle Scholar
  2. 2.
    Heilman KM, Watson RT, Valenstein E (1985) Neglect and related disorders. In: Heilman KM, Valenstein E (eds) Clinical neuropsychology. Oxford University Press, New York, pp 243–293Google Scholar
  3. 3.
    Albert ML (1973) A simple test of neglect. Neurology 23:658–664PubMedCrossRefGoogle Scholar
  4. 4.
    Jeannerod M, Biguer B (1987) The directional coding of reaching movements. A visuomotor conception of spatial neglect. In: Jeannerod M (ed) Neurophysiological and neuropsychological aspects of neglect. Elsevier Science, Amsterdam, pp 87–113CrossRefGoogle Scholar
  5. 5.
    Bisiach E (1999) Unilateral neglect and related disorders. In: Denes F, Pizzamiglio L (eds) Handbook of clinical and experimental neuropsychology. Psychology Press, HoveGoogle Scholar
  6. 6.
    Kerkhoff G (2001) Spatial hemineglect in humans. Prog Neurobiol 63:1–27PubMedCrossRefGoogle Scholar
  7. 7.
    Halligan PW, Fink GR, Marshall JC, Vallar G (2003) Spatial cognition: evidence from visual neglect. Trends Cogn Sci 7:125–133PubMedCrossRefGoogle Scholar
  8. 8.
    Vallar G (2001) Extrapersonal visual unilateral spatial neglect and its neuroanatomy. Neuroimage 14:552–558CrossRefGoogle Scholar
  9. 9.
    Hécaen H, Penfield W, Bertrand C, Malmo R (1956) The syndrome of apractognosia due to lesions of the minor cerebral hemisphere. Arch Neurol Psychiatry 57:400–434CrossRefGoogle Scholar
  10. 10.
    Heilman KM, Bowers D, Valenstein E, Watson RT (1983) Localization of lesion in neglect. In: Kertesz A (ed) Localization in neuropsychology. Academic, New York, pp 471–492Google Scholar
  11. 11.
    Karnath HO, Ferber S, Himmelbach M (2001) Spatial awareness is a function of the temporal not the posterior parietal lobe. Nature 411:950–953PubMedCrossRefGoogle Scholar
  12. 12.
    Karnath HO, Himmelbach M, Rorden C (2002) The subcortical anatomy of human spatial neglect: putamen, caudate nucleus and pulvinar. Brain 125:350–360PubMedCrossRefGoogle Scholar
  13. 13.
    Mort D, Malhotra P, Mannan S, Rorden C, Pambakian A, Kennard C, Husain M (2003) The anatomy of visual neglect. Brain 126:1986–1997PubMedCrossRefGoogle Scholar
  14. 14.
    Doricchi F, Tomaiuolo F (2003) The anatomy of neglect without hemianopia: a key role for parietal-frontal disconnection? Neuroreport 14:2239–2243PubMedCrossRefGoogle Scholar
  15. 15.
    Thiebaut de Schotten M, Urbanski M, Duffau H, Volle E, Lévy R, Dubois B, Bartolomeo P (2005) Direct evidence for a parietal-frontal pathway subserving spatial awareness in humans. Science 309:2226–2228PubMedCrossRefGoogle Scholar
  16. 16.
    Husain M, Rorden C (2003) Non-spatially lateralized mechanisms in hemispatial neglect. Nat Neurosci 4:26–36CrossRefGoogle Scholar
  17. 17.
    Parton A, Malhotra P, Husain M (2004) Hemispatial neglect. J Neurol Neurosurg Psychiatry 75:13–21PubMedGoogle Scholar
  18. 18.
    Kinsbourne M (1993) Orientational bias model of unilateral neglect: evidence from attentional gradients with hemispace. In: Robertson IH, Marshall JC (eds) Unilateral neglect: clinical and experimental studies. Erlbaum, Hillstale, pp 63–86Google Scholar
  19. 19.
    Posner MI, Walker JA, Friedrich FJ, Rafal RD (1984) Effects of parietal injury on covert orienting of attention. J Neurosci 4:1863–1874PubMedGoogle Scholar
  20. 20.
    Gainotti G, D’Erme P, Bartolomeo P (1991) Early orientation of attention toward the half space ipsilateral to the lesion in patients with unilateral brain damage. J Neurol Neurosurg Psychiatry 54:1082–1089PubMedCrossRefGoogle Scholar
  21. 21.
    Smania N, Martini MC, Gambina G, Tomelleri G, Palamara A, Natale E, Marzi CA (1998) The spatial distribution of visual attention in hemineglect and extinction patients. Brain 121:1759–1770PubMedCrossRefGoogle Scholar
  22. 22.
    Bisiach E, Berti A (1987) Dyschiria. An attempt at its systemic explanation. In: Jeannerod M (ed) Neurophysiological and neuropsychological aspects of spatial neglect. North Holland, Amsterdam, pp 183–201CrossRefGoogle Scholar
  23. 23.
    Karnath HO (1997) Spatial orientation and the representation of space with parietal lobe lesions. Philos Trans R Soc Lond B 352:1411–1419CrossRefGoogle Scholar
  24. 24.
    Mattingley JB, Bradshaw JL, Phillips JG (1992) Impairments of movement initiation and execution in unilateral neglect. Directional hypokinesia and bradykinesia. Brain 115:1849–1874PubMedCrossRefGoogle Scholar
  25. 25.
    Husain M, Mattingley JB, Rorden C, Kennard C, Driver J (2000) Distinguishing sensory and motor biases in parietal and frontal neglect. Brain 123:1643–1659PubMedCrossRefGoogle Scholar
  26. 26.
    Held JP, Pierrot-Deseilligny E, Bussel B, Perrigot M, Malier M (1975) Devenir des hémiplégies vasculaires par atteinte sylvienne en fonction du côté de la lésion. Ann Réadapt Méd Phys 4:592–604Google Scholar
  27. 27.
    Denes G, Semenza C, Stoppa E, Lis A (1982) Unilateral spatial neglect and recovery from hemiplegia: a follow-up study. Brain 105:543–552PubMedCrossRefGoogle Scholar
  28. 28.
    Fullerton KJ, McSherry D, Stout RW (1986) Albert’s test: a neglected test of perceptual neglect. Lancet 327:430–432CrossRefGoogle Scholar
  29. 29.
    Katz N, Hartman-Macir A, Ring H, Soroker N (1999) Functional disability and rehabilitation outcome in right hemisphere damaged patients with and without unilateral spatial neglect. Arch Phys Med Rehabil 80:379–384PubMedCrossRefGoogle Scholar
  30. 30.
    Jehkonen M, Ahonen JP, Dastidar P, Koivisto AM, Laippala P, Vikki J, Molnar G (2000) Visual neglect as a predictor of functional outcome one year after stroke. Acta Neurol Scand 101:195–201PubMedCrossRefGoogle Scholar
  31. 31.
    Jehkonen M, Laihosalo M, Kettunen J (2006) Anosognosia after stroke: assessment, occurrence, subtypes and impact on functional outcome reviewed. Acta Neurol Scand 114:293–306PubMedCrossRefGoogle Scholar
  32. 32.
    Cassidy TP, Lewis S, Gray CS (1998) Recovery from visuosptial neglect in stroke patients. J Neurol Neurosurg Psychiatry 64:555–557PubMedCrossRefGoogle Scholar
  33. 33.
    Farnè A, Buxbaum LJ, Ferraro M, Frassinetti F, Whyte J, Veramonti T, Angeli V, Coslett HB, Ladavas E (2004) Patterns of spontaneous recovery of neglect and associated disorders in acute right brain-damaged paptients. J Neurol Neurosurg Psychiatry 75:1401–1410PubMedCrossRefGoogle Scholar
  34. 34.
    Luauté J, Halligan P, Rode G, Jacquin-Courtois S, Boisson D (2006) Prism adaptation first among equals in alleviating left neglect. A review. Restor Neurol Neurosci 24:409–418PubMedGoogle Scholar
  35. 35.
    Luauté J, Halligan P, Rossetti Y, Rode G, Boisson D (2006) Visuo-spatial neglect: a systematic review of current interventions and their effectiveness. Neurosci Biobehav Rev 30:961–982PubMedCrossRefGoogle Scholar
  36. 36.
    Diller L, Weinberg J (1977) Hemi-inattention in rehabilitation: the evolution of a rational remediation program. Adv Neurol 18:63–82PubMedGoogle Scholar
  37. 37.
    Pizzamiglio L, Antonucci G, Judica A, Montenero P, Razzano C, Zoccolotti P (1992) Cognitive rehabilitation of the hemineglect disorder in chronic patients with unilateral right brain damage. J Clin Exp Neuropsychol 14:901–923PubMedCrossRefGoogle Scholar
  38. 38.
    Antonucci G, Guariglia C, Judica A, Magnotti L, Paolucci S, Pizzamiglio L, Zoccolotti P (1995) Effectiveness of neglect rehabilitation in a randomized group study. J Clin Exp Neuropsychol 17:383–389PubMedCrossRefGoogle Scholar
  39. 39.
    Paolucci S, Antonucci G, Guariglia C, Magnotti L, Pizzamiglio L, Zoccolotti P (1996) Facilitatory effect of neglect rehabilitation on the recovery of left hemiplegic stroke patients: a cross-over study. J Neurol 243:308–314PubMedCrossRefGoogle Scholar
  40. 40.
    Rubens AB (1985) Caloric stimulation and unilateral visual neglect. Neurology 35:1019–1024PubMedCrossRefGoogle Scholar
  41. 41.
    Vallar G, Guariglia C, Rusconi ML (1997) Modulation of the neglect syndrome by sensory stimulation. In: Parietal lobe contributions to orientation in 3D space. Springer, Heidelberg, pp 555–578Google Scholar
  42. 42.
    Rossetti Y, Rode G (2002) Reducing spatial neglect by visual and other sensory manipulations: non-cognitive (physiological) routes to the rehabilitation of a cognitive disorder. In: Karnath HO, Milner AD, Vallar G (eds) The cognitive and neural bases of spatial neglect. Oxford University Press, New York, pp 375–396Google Scholar
  43. 43.
    Kerkhoff G (2003) Modulation and rehabilitation of spatial neglect by sensory stimulation. Prog Brain Res 142:257–271PubMedCrossRefGoogle Scholar
  44. 44.
    Thimm M, Fink GR, Küst J, Karbe H, Willmes K, Sturm W (2009) Recovery from hemineglect: differential neurobiological effects of optokinetic stimulation and alertness training. Cortex 45:850–862PubMedCrossRefGoogle Scholar
  45. 45.
    Bottini G, Sterzi R, Paulesu E, Vallar G, Cappa SF, Erminio F, Passingham RE, Frith CD, Frackowiak RS (1994) Identification of the central vestibular projections in man: a positron emission tomography activation study. Exp Brain Res 99:164–169PubMedCrossRefGoogle Scholar
  46. 46.
    Bottini G, Karnath HO, Vallar G, Sterzi R, Frith CD, Frackowiak RS, Paulesu E (2001) Cerebral representations for egocentric space: functional-anatomical evidence from caloric vestibular stimulation and neck vibration. Brain 124:1182–1196PubMedCrossRefGoogle Scholar
  47. 47.
    Jeannerod M, Rossetti Y (1993) Visuomotor coordination as a dissociable visual function: experimental and clinical evidence. In: Kennard CC (ed) Visual perceptual defect. I.P.R. Baillere Tindall Ltd, Baillere’s Clinical Neurology, London, pp 439–460Google Scholar
  48. 48.
    Redding GM, Rossetti Y, Wallace B (2005) Applications of prism adaptation: a tutorial in theory and method. Neurosci Biobehav Rev 29:431–444PubMedCrossRefGoogle Scholar
  49. 49.
    Rode G, Rossetti Y, Li L, Boisson D (1998) The effect of prism adaptation on neglect for visual imagery. Behav Neurol 11:251–258PubMedGoogle Scholar
  50. 50.
    Rode G, Revol P, Rossetti Y, Boisson D, Bartolomeo P (2007) Looking while imagining. The influence of visual input on representational neglect. Neurology 68:432–437PubMedCrossRefGoogle Scholar
  51. 51.
    Schenkenberg T, Bradford DC, Ajax ET (1980) Line bisection with neurologic impairment. Neurology 30:509–517PubMedCrossRefGoogle Scholar
  52. 52.
    Rossetti Y, Rode G, Pisella L, Farnè A, Li L, Boisson D, Perenin MT (1998) Prism adaptation to a rightward optical deviation rehabilitates left hemispatial neglect. Nature 395:166–169PubMedCrossRefGoogle Scholar
  53. 53.
    Farnè A, Rossetti Y, Toniolo S, Ladavas E (2002) Ameliorating neglect with prism adaptation: visuo-manual and visuo-verbal measures. Neuropsychologia 40:718–729PubMedCrossRefGoogle Scholar
  54. 54.
    Pisella L, Rode G, Farnè A, Boisson D, Rossetti Y (2002) Dissociated long lasting improvements of straight-ahead pointing and line bisection tasks in two unilateral neglect patients. Neuropsychologia 40:327–334PubMedCrossRefGoogle Scholar
  55. 55.
    Frassinetti F, Angeli V, Meneghello F, Avanzi S, Ladavas E (2002) Long-lasting amelioration of visuospatial neglect by prism adaptation. Brain 125:608–623PubMedCrossRefGoogle Scholar
  56. 56.
    McIntosh RM, Rossetti Y, Milner AD (2002) Prism adaptation improves chronic visual and haptic neglect. Cortex 38:309–320PubMedCrossRefGoogle Scholar
  57. 57.
    Morris AP, Kritikos A, Berberovic N, Pisella L, Chambers CD, Mattingley J (2004) Prism adaptation and spatial attention: a study of visual search in normals and patients with unilateral neglect. Cortex 40:703–721PubMedCrossRefGoogle Scholar
  58. 58.
    Rode G, Klos T, Courtois-Jacquin S, Rossetti Y (2006) Neglect and prism adaptation. A new therapeutic tool for saptial cognition disorders. Restor Neurol Neurosci 24:347–356PubMedGoogle Scholar
  59. 59.
    Rode G, Pisella L, Marsal L, Mercier S, Rossetti Y, Boisson D (2006) Prism adaptation improves spatial dysgraphia following right brain damage. Neuropsychologia 44:2487–2493PubMedCrossRefGoogle Scholar
  60. 60.
    Humphreys GW, Watelet A, Riddoch MJ (2006) Long-term effects of prism adaptation in chronic visual neglect: a single case study. Cogn Neuropsychol 23:463–478PubMedCrossRefGoogle Scholar
  61. 61.
    Keane S, Turner C, Sherrington C, Beard JR (2006) Use of Fresnel prism glasses to treat stroke patients with hemispatial neglect. Arch Phys Med Rehabil 87:1668–1672PubMedCrossRefGoogle Scholar
  62. 62.
    Serino A, Bonifazi S, Pierfederici L, Ladavas E (2007) Neglect treatment by prism adaptation: what recovers and for how long. Neuropsychol Rehabil 17:657–687PubMedCrossRefGoogle Scholar
  63. 63.
    Shiraishi H, Yamakawa Y, Itou A, Muraki T, Asada T (2008) Long-term effects of prism adaptation on chronic neglect after stroke. NeuroRehabilitation 23:137–151PubMedGoogle Scholar
  64. 64.
    Sarri M, Greenwood R, Kalra L, Husain M, Driver J (2008) Prism adaptation aftereffects in stroke patients with spatial neglect: Pathological effects on subjective straight ahead but not visual open-loop pointing. Neuropsychologia 46:1069–1080PubMedCrossRefGoogle Scholar
  65. 65.
    Nys GM, Seurinck R, Dijkerman HC (2008) Prism adaptation moves neglect-related perseveration to contralesional space. Cogn Behav Neurol 21:249–253PubMedCrossRefGoogle Scholar
  66. 66.
    Nys GMS, de Haan EHF, Kunneman A, de Kort PLM, Dijkerman HC (2008) Acute neglect rehabilitationusing repetitive prism adaptation: a randomized placebo-controlled trial. Restor Neurol Neurosci 26:1–12PubMedGoogle Scholar
  67. 67.
    Serino A, Barbiani M, Rinaldesi ML, Ladavas E (2009) Effectivenes of prism adaptation in neglect rehabilitation. A controlled trial study. Stroke 40:1392–1398PubMedCrossRefGoogle Scholar
  68. 68.
    Saevarsson S, Kristjánsson A, Hildebrandt H, Halsband U (2009) Prism adaptation improves visual search in hemispatial neglect. Neuropsychologia 47:717–725PubMedCrossRefGoogle Scholar
  69. 69.
    Saevarsson S, Kristjansson A, Halsband U (2010) Strength in numbers: combining neck vibration and prism adaptation produces additive therapeutic effects in unilateral neglect. Neuropsychol Rehabil 20:704–724Google Scholar
  70. 70.
    Turton AJ, O’Leary K, Gabb J, Woodward R, Gilchrist ID (2010) A single blinded randomised controlled pilot trial of prism adaptation for improving self-care in stroke patients with neglect. Neuropsychol Rehabil 20:180–196PubMedCrossRefGoogle Scholar
  71. 71.
    Eramudugolla R, Boyce A, Irvine DR, Mattingley JB (2010) Effects of prismatic adaptation on spatial gradients in unilateral neglect: a comparison of visual and auditory target detection with central attentional load. Neuropsychologia 48:2681–2692Google Scholar
  72. 72.
    Vangkilde S, Habekost T (2010) Finding Wally: prism adaptation improves visual search in chronic neglect. Neuropsychologia 48:1994–2004PubMedCrossRefGoogle Scholar
  73. 73.
    Striemer CL, Danckert J (2010) Dissociating perceptual and motor effects of prism adaptation in neglect. Neuroreport 21:436–441Google Scholar
  74. 74.
    Dijkerman HC, McIntosh RD, Rossetti Y, Tilikete C, Roberts RC, Milner AD (2003) Ocular scanning and perceptual size distortion in hemispatial neglect: effects of prism adaptation and sequential stimulus presentation. Exp Brain Res 153:220–230PubMedCrossRefGoogle Scholar
  75. 75.
    Angeli V, Benassi MG, Ladavas E (2004) Recovery of oculo-motor bias in neglect patients after prism adaptation. Neuropsychologia 42:1223–1234PubMedCrossRefGoogle Scholar
  76. 76.
    Sarri M, Kalra L, Greenwood R, Driver J (2006) Prism adaptation changes perceptual awareness for chimeric visual objects but not for chimeric faces in spatial neglect after right-hemisphere stroke. Neurocase 12:127–135PubMedCrossRefGoogle Scholar
  77. 77.
    Bultitude JH, Rafal RD, List A (2009) Prism adaptation reverses the local processing bias in patients with right temporo-parietal junction lesions. Brain 132:1669–1677PubMedCrossRefGoogle Scholar
  78. 78.
    Ferber S, Danckert J, Joanisse M, Goltz HC, Goodale MA (2003) Eye movements tell only half the story. Neurology 60:1826–1829PubMedCrossRefGoogle Scholar
  79. 79.
    Serino A, Angeli V, Frassinetti F, Ladavas E (2006) Mechanisms underlying neglect recovery after prism adaptation. Neuropsychologia 44:1068–1078PubMedCrossRefGoogle Scholar
  80. 80.
    Datié AM, Paysant J, Destainville S, Sagez A, Beis JM, André JM (2006) Eye movements and visuoverbal descriptions exhibit heterogeneous and dissociated patterns before and after prismatic adaptation in unilateral spatial neglect. Eur J Neurol 13:772–779PubMedCrossRefGoogle Scholar
  81. 81.
    Maravita A, McNeil J, Malhotra P, Greenwood R, Husain M, Driver J (2003) Prism adaptation can improve contralesional tactile perception in neglect. Neurology 60:1829–1831PubMedCrossRefGoogle Scholar
  82. 82.
    Dijkerman HC, Webeling M, Walter JM, Groet E, van Zandvoort MJ (2004) A long-lasting improvement of somatosensory function after prism adaptation, a case study. Neuropsychologia 42:1697–1702PubMedCrossRefGoogle Scholar
  83. 83.
    Jacquin-Courtois S, Rode G, Pavani F, O’Shea J, Giard MH, Boisson D, Rossetti Y (2010) Effect of prism adaptation on left dichotic listening deficit in neglect patients: glasses to hear better? Brain 133:895–908PubMedCrossRefGoogle Scholar
  84. 84.
    Rode G, Rossetti Y, Boisson D (2001) Prism adaptation improves representational neglect. Neuropsychologia 39:1250–1254PubMedCrossRefGoogle Scholar
  85. 85.
    Rossetti Y, Jacquin-Courtois S, Rode G, Ota H, Michel C, Boisson D (2004) Does action make the link between number and space representation? Visuo-manual adaptation improves number bisection in unilateral neglect. Psychol Sci 15:426–430PubMedCrossRefGoogle Scholar
  86. 86.
    Jacquin-Courtois S, Rode G, Boisson D, Rossetti Y (2008) Wheel-chair driving improvement following visuo-manual prism adaptation. Cortex 44:90–96PubMedCrossRefGoogle Scholar
  87. 87.
    Watanabe S, Amimoto K (2010) Generalization of prism adaptation for whellchair driving task in patients with unilateral spatial neglect. Arch Phys Med Rehabil 91:443–447PubMedCrossRefGoogle Scholar
  88. 88.
    Sumitani M, Shibata M, Yagisawa M, Mashimo T, Miyauchi S (2006) Prism adaptation to optical deviation alleviates complex regional pain syndrome: longitudinal single case study. Neurorehabil Neural Repair 20:141–142Google Scholar
  89. 89.
    Sumitani M, Rossetti Y, Shibata M, Matsuda Y, Sakaue G, Inoue T, Mashimo T, Miyauchi S (2007) Prism adaptation to optical deviation alleviates pathological pain. Neurology 68:128–133PubMedCrossRefGoogle Scholar
  90. 90.
    Rode G, Pisella L, Rossetti Y, Farnè A, Boisson D (2003) Bottom-up transfer of sensory-motor plasticity to recovery of spatial cognition: visuomotor adaptation and spatial neglect. Prog Brain Res 142:273–287PubMedCrossRefGoogle Scholar
  91. 91.
    Nijboer T, Vree A, Dijkerman C, Van der Stigchel S (2010) Prism adaptation influences perception but not attention: evidence from antisaccades. Neuroreport 21:386–389PubMedCrossRefGoogle Scholar
  92. 92.
    Weiner MJ, Hallett M, Funkenstein HH (1983) Adaptation to lateral displacement of vision in patients with lesions of the central nervous system. Neurology 33:766–772PubMedCrossRefGoogle Scholar
  93. 93.
    Clower DM, Hoffman JM, Votaw JR, Fabert TL, Woods R, Alexander GE (1996) Role of posterior parietal cortex in the recalibration of visually guide reaching. Nature 383:618–621PubMedCrossRefGoogle Scholar
  94. 94.
    Pisella L, Michel C, Grea H, Tilikete C, Vighetto A, Rossetti Y (2004) Preserved prism adaptation in bilateral optic ataxia: strategic versus adaptive reaction to prisms. Exp Brain Res 156:399–408PubMedCrossRefGoogle Scholar
  95. 95.
    Rossetti Y, Pisella L, Colent C (2000) A cerebellar therapy for a parietal deficit? (abstract). In: Weiss PHH (ed) Action and visuo-spatial attention, neurobiological bases and disorders. Life Sciences, Reihe Lebenswissenschaften, Forschungszentrum Jülich GmbH, Germany, p 21Google Scholar
  96. 96.
    Pisella L, Rode G, Farnè A, Tilikete C, Rossetti Y (2006) Prism adaptation in the rehabilitation of patients with visuo-spatial cognitive disorders. Curr Opin Neurol 19:534–542PubMedCrossRefGoogle Scholar
  97. 97.
    Pisella L, Rossetti Y, Michel C, Rode G, Boisson D, Pélisson D, Tilikete C (2005) Ipsidirectional impairment of prism adaptation after unilateral lesion of anterior cerebellum. Neurology 65:150–152PubMedCrossRefGoogle Scholar
  98. 98.
    Martin TA, Keating JG, Goodkin HP, Bastian AJ, Thatch WT (1996) Throwing while looking through prisms, I Focal olivocerebellar lesions impair adaptation. Brain 119:1183–1198PubMedCrossRefGoogle Scholar
  99. 99.
    Schmahmann JD (1998) Dysmetria of thought: clinical consequences of cerebellar dysfunction on cognition and affect. Trends Cogn Sci 2:362–371PubMedCrossRefGoogle Scholar
  100. 100.
    Luauté J, Michel C, Rode G, Pisella L, Jacquin-Courtois S, Costes N, Cotton F, le Bars D, Boisson D, Halligan P, Rossetti Y (2006) Functional anatomy of the therapeutic effects of prism adaptation on left neglect. Neurology 66:1859–1867PubMedCrossRefGoogle Scholar
  101. 101.
    Danckert J, Ferber S, Goodale MA (2008) Direct effects of prismatic lenses on visuomotor control: an event-related functional MRI study. Eur J Neurosci 28:1696–1704PubMedCrossRefGoogle Scholar
  102. 102.
    Luauté J, Schwartz S, Rossetti Y, Spiridon M, Rode G, Boisson D, Vuilleumier P (2009) Dynamic changes in brain activity during prism adaptation. J Neurosci 29:169–178PubMedCrossRefGoogle Scholar
  103. 103.
    Chapman HL, Eramudugolla R, Gavrilescu M, Strudwick MW, Loftus A, Cunnington R, Mattingley JB (2010) Neural mechanismsunderlying spatial realignment during adaptation to optical wedge prisms. Neuropsychologia 48:2595–2601Google Scholar
  104. 104.
    Pisella L, Mattingley JB (2004) The contribution of spatial remapping impairments to ­unilateral visual neglect. Neurosci Biobehav Rev 28:181–200PubMedCrossRefGoogle Scholar
  105. 105.
    Redding GM, Wallace B (2006) Prism adaptation and unilateral neglect: review and analysis. Neuropsychologia 44:1–20PubMedCrossRefGoogle Scholar
  106. 106.
    Rousseaux M, Bernati T, Saj A, Kozlowski O (2006) Ineffectiveness of prism adaptation on spatial neglect signs. Stroke 37:542–543PubMedCrossRefGoogle Scholar
  107. 107.
    Schindler I, Kerkhoff G, Karnath HO, Keller I, Goldenberg G (2002) Neck muscle vibration induces lasting recovery in spatial neglect. J Neurol Neurosurg Psychiatry 73:412–419PubMedCrossRefGoogle Scholar
  108. 108.
    Wiart L, Côme AB, Debelleix X, Petit H, Joseph PA, Mazaux JM, Barat M (1997) Unilateral neglect syndrome rehabilitation by trunk rotation and scanning training. Arch Phys Med Rehabil 78:424–429PubMedCrossRefGoogle Scholar
  109. 109.
    Polanowska K, Seniow J, Paprot E, Lesniak M, Czlonkowska A (2009) Left-hand somatosensory stimulation combined with visual scanning training in rehabilitation for post-stroke hemineglect: a randomised, double-blind study. Neuropsychol Rehabil 19:364–382PubMedCrossRefGoogle Scholar
  110. 110.
    Robertson IH, Manly T, Beschin N, Daini R, Haeske-Dewick H, Hömberg V, Jehkonen M, Pizzamiglio G, Shiel A, Weber E (1997) Auditory sustained attention is a marker of unilateral spatial neglect. Neuropsychologia 35:1527–1532PubMedCrossRefGoogle Scholar
  111. 111.
    Husain M, Shapiro K, Martin J, Kennard C (1997) Abnormal temporal dynamics of visual attention in spatial neglect patients. Nature 385:154–156PubMedCrossRefGoogle Scholar
  112. 112.
    Battelli L, Cavanagh P, Intriligator J, Tramo MJ, Hénaff MA, Michel F, Barton JJ (2001) Unilateral right parietal damage leads to bilateral deficit for high-level motion. Neuron 32:985–995PubMedCrossRefGoogle Scholar
  113. 113.
    Doricchi F, Incoccia C (1998) Seeing only the right half of the forest but cutting down all the trees? Nature 394:75–78PubMedCrossRefGoogle Scholar
  114. 114.
    Husain M, Mannan S, Hodgson T, Wojciulik E, Driver J, Kennard C (2001) Impaired spatial working memory across saccades contributes to abnormal search in parietal neglect. Brain 124:942–952CrossRefGoogle Scholar
  115. 115.
    Malhotra P, Jäger HR, Parton A, Greenwood R, Playford ED, Brown MM, Driver J, Husain M (2005) Spatial working memory capacity in unilateral neglect. Brain 128:424–435PubMedCrossRefGoogle Scholar
  116. 116.
    Robertson IH (2001) Do we need the “lateral” in unilateral neglect? Spatially nonselective attention deficits in unilateral neglect and their implications for rehabilitation. Neuroimage 14:585–590CrossRefGoogle Scholar
  117. 117.
    Malhotra P, Parton AD, Greenwood R, Husain M (2006) Noradrenergic modulation of space exploration in visual neglect. Ann Neurol 59:186–190PubMedCrossRefGoogle Scholar
  118. 118.
    Seron X, Rossetti Y, Vallat-Azouvi C, Pradat-Diehl P, Azouvi P (2008) Cognitive rehabilitation. Rev Neurol 164:S154–S163PubMedCrossRefGoogle Scholar
  119. 119.
    O’Shea J (2009) Cognitive neurology: stimulating research on neglect. Curr Biol 19:R76–R77PubMedCrossRefGoogle Scholar
  120. 120.
    Fierro B, Brighina F, Bisiach E (2006) Improving neglect by TMS. Behav Neurol 17:169–176PubMedGoogle Scholar
  121. 121.
    Koch O, Oliveri M, Cheeran B, Ruge D, Lo Gerfo E, Salerno S, Torriero S, Marconi B, Mori F, Driver J, Rothwell JC, Caltagirone C (2008) Hyperexcitability of parietal-motor functional connections in the intact left-hemisphere of patients with neglect. Brain 131:3147–3155PubMedCrossRefGoogle Scholar
  122. 122.
    Berberovic N, Pisella L, Morris AP, Mattingley JB (2004) Prismatic adaptation reduces biased temporal order judgement in spatial neglect. Neuroreport 15:1199–1204PubMedCrossRefGoogle Scholar
  123. 123.
    Striemer C, Danckert J (2007) Prism adaptation reduces the disengage deficit in right brain damage patients. Neuroreport 18:99–103PubMedCrossRefGoogle Scholar
  124. 124.
    Nijboer TC, McIntosh RD, Nys GM, Dijkerman HC, Milner AD (2008) Prism adaptation improves voluntary but not automatic orienting in neglect. Neuroreport 19:293–298PubMedCrossRefGoogle Scholar
  125. 125.
    Kerkhoff G, Rossetti Y (2006) Plasticity in spatiel neglect: recovery and rehabilitaion Restor Neurol Neurosci 24:201–206PubMedCrossRefGoogle Scholar
  126. 126.
    Michel C, Pisella L, Prablanc C, Rode G, Rossetti Y (2007) Enhancing visuomotor adaptation by reducing error signals: single-step (aware) versus multiple-step (unaware) exposure to wedge prisms. J Cogn Neurosci 19:341–350PubMedCrossRefGoogle Scholar
  127. 127.
    Riddoch MJ, Humphreys GW (1983) The effect of cueing on unilateral neglect. Neuropsychologia 21:589–599PubMedCrossRefGoogle Scholar
  128. 128.
    Rossetti Y, Koga K, Mano T (1993) Prismatic displacement of vision induces transient changes in the timing of eye-hand coordination. Percept Psychophys 54:355–364PubMedCrossRefGoogle Scholar
  129. 129.
    Samuelsson H, Jensen C, Ekholm S, Naver H, Blomstrand C (1997) Anatomical and neurological correlates of acute and chronic visuospatial neglect following right hemisphere stroke. Cortex 33:271–285PubMedCrossRefGoogle Scholar
  130. 130.
    Tilikete C, Rode G, Rossetti Y, Li L, Pichon J, Boisson D (2001) Prism adaptation to rightward optical deviation improves postural imbalance in left hemiparetic patients. Curr Biol 11:524–528PubMedCrossRefGoogle Scholar
  131. 131.
    Tsang MH, Sze KH, Fong KN (2009) Occupational therapy treatment with right half-field eye patching for patients with subacute stroke and unilatreal neglect: a randomised controlled trial. Disabil Rehabil 31:630–637PubMedCrossRefGoogle Scholar
  132. 126.
    Mizuno K, Tsuji T, Takebayashi T, Fujiwara T, Hase K, Liu M. Prism adaptation therapy enhances rehabilitation of stroke patients with unilateral spatial neglect: a randomized, controlled trial. Neurorehabil Neural Repair (in press)PubMedCrossRefGoogle Scholar

Copyright information

© Springer 2011

Authors and Affiliations

  • Sophie Jacquin-Ciourtois
    • 1
    • 2
    • 3
  • Jacinta O’Shea
    • 4
  • Jacques Luauté
    • 1
    • 2
    • 3
  • Laure Pisella
    • 1
    • 2
  • Alessandro Farné
    • 1
    • 2
  • Patrice Revol
    • 1
    • 2
    • 3
  • Gilles Rode
    • 1
    • 2
    • 3
  • Yves Rossetti
    • 1
    • 2
    • 3
  1. 1.Centre de recherche en Neurosciences de Lyon, Inserm U1028, CRNS UMR5092BronFrance
  2. 2.Université de Lyon, Université Lyon 1LyonFrance
  3. 3.Service de Rééducation Neurologique, Plate-forme Mouvement et HandicapHôpital Henry Gabrielle, Hospices Civils de LyonSt Genis LavalFrance
  4. 4.Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB), Nuffield Department of Clinical NeurosciencesUniversity of OxfordOxfordUK

Personalised recommendations