Molecular and Electrophysiological Approaches for Functional Recovery in Patients with Injured Spinal Cord

  • Toru Ogata
  • Noritaka Kawashima
  • Kimitaka Nakazawa
  • Masami Akai
Conference paper


Because patients with an injured spinal cord face severe functional ­deficits, novel therapeutic approaches are required to treat this traumatic disorder. Recent advances in molecular biology and electrophysiology have rendered approaches based on these two subjects important in this field. A molecular approach involving tissue engineering is beneficial for preserving or restoring the neural ­circuit, i.e., the so-called “hardware” of the spinal cord. On the other hand, the ­electrophysiological approach has advantages such as modulation and analysis of use-dependent plastic changes in neural functioning of human subjects, which ­corresponds to the “software” of the spinal cord. Because varied biological processes are triggered after spinal cord injury, we should use either approach, or both, depending on the clinical problem that needs to be solved.


Spinal Cord Injury Transcranial Magnetic Stimulation Central Pattern Generator Injured Spinal Cord Incomplete Spinal Cord Injury 
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Copyright information

© Springer 2011

Authors and Affiliations

  • Toru Ogata
    • 1
  • Noritaka Kawashima
    • 1
  • Kimitaka Nakazawa
    • 1
  • Masami Akai
    • 1
  1. 1.Department of Rehabilitation for Movement FunctionsResearch Institute of National Rehabilitation Center for Persons with Disabilities (NRCD)TokorozawaJapan

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