Abstract
HBV carrier rate is now 0.67% in Japanese population. The most prevalent HBV genotype is genotype C (85%) in patients with chronic HBV carriers in Japan. Hepatitis activity is more severe and response to anti-viral therapy is poor in genotype C compared with genotype B. There are questions whether we should use lamivudine for long-term.
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Kobayashi S, Ide T, Sata M. Detection of YMDD motif mutations in some lamivudineuntreated asymptomatic hepatitis B virus carriers. J Hepatol 2001;34:584–586.
Lok AS, Hussain M, Cursano C, Margotti M, Gramenzi A, Grazi GL, Jovine E, et al. Evolution of hepatitis B virus polymerase gene mutations in hepatitis B e antigen-negative patients receiving lamivudine therapy. Hepatology 2000;32:1145–1153.
Ide T, Kumashiro R, Suzuki H, Tanikawa K, Sata M. Two-year follow-up study after treatment with lamivudine for chronic hepatitis B: seven cases reported. Hepatol Res 2000;17:197–204.
Liaw YF, Tsai SL, Chien RN, Yeh CT, Chu CM. Prednisolone priming enhances Thl response and efficacy of subsequent lamivudine therapy in patients with chronic hepatitis B. Hepatology 2000;32:604–609.
Serfaty L, Thabut D, Zoulim F, Andreani T, Chazouilleres O, Carbonell N, Loria A, et al. Sequential treatment with lamivudine and interferon monotherapies in patients with chronic hepatitis B not responding to interferon alone: results of a pilot study. Hepatology 2001;34:573–577.
Tatulli I, Francavilla R, Rizzo GL, Vinciguerra V, Ierardi E, Amoruso A, Panella C, Francavilla A. Lamivudine and alpha-interferon in combination long term for precore mutant chronic hepatitis B. J Hepatol 2001;35:805–810.
Liu CJ, Chen PJ, Lai MY, Kao JH, Chen DS. Hepatitis B virus variants in patients receiving lamivudine treatment with breakthrough hepatitis evaluated by serial viral loads and full-length viral sequences. Hepatology 2001;34:583–589.
Ide T, Kumashiro R, Sata M, et al. A real-time quantitative polymerase chain reaction method for hepatitis B virus in patients with chronic hepatitis B treated with lamivudine. Am J Gastroenterol 2003;98:2048–51.
Ide T, Kumashiro R, Hino T, Murashima S, Ogata K, Koga Y, Sata M. Transcription-mediated amplification is more useful in the follow-up of patients with chronic hepatitis B treated with lamivudine. Hepatol Res 2001;21:76–84.
Villeneuve JP, Condreay LD, Willems B, Pomier-Layrargues G, Fenyves D, Bilodeau M, Leduc R, Peltekian K, Wong F, Margulies M, Heathcote EJ. Lamivudine treatment for decompensated cirrhosis resulting from chronic hepatitis B. Hepatology 2000;31:207–210.
Kapoor D, Guptan RC, Wakil SM, Kazim SN, Kaul R, Agarwal SR, Raisuddin S, Hasnain SE, Sarin SK. Beneficial effects of lamivudine in hepatitis B virus-related decompensated cirrhosis. J Hepatol 2000;33:308–312.
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© 2004 Springer Japan
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Sata, M. (2004). Lamivudine Therapy of Hepatitis B in Japan. In: Omata, M., Okita, K. (eds) Therapy for Viral Hepatitis and Prevention of Hepatocellular Carcinoma. Springer, Tokyo. https://doi.org/10.1007/978-4-431-53977-3_3
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DOI: https://doi.org/10.1007/978-4-431-53977-3_3
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-67975-2
Online ISBN: 978-4-431-53977-3
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