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Living Donor Liver Transplantation for Hepatitis B and C Cirrhosis

  • Yasuhiko Sugawara
  • Masatoshi Makuuchi
Conference paper

Abstract

Recent advancements and results of living donor liver transplantation for viral hepatitis and cirrhosis are reviewed. Living donor liver transplantation has a significant advantage over cadaveric liver transplantation in hepatitis B virus - positive patients. The scheduled operation enables limited preoperative lamivudine administration, which reduces viral load without developing viral mutants. Subsequent indefinite hepatitis B immunoglobulin use in the postoperative period is a rational strategy for preventing viral re-infection. In contrast, preliminary results indicate that live liver donation might be disadvantageous for hepatitis C virus - positive patients. Preemptive antiviral therapy after transplantation might be necessary to overcome rapid viral recurrence and graft failure. Living donor liver transplantation is important for patients with cirrhosis due to viral hepatitis because of cadaveric organ shortage.

Keywords

Liver Transplantation Live Donor Liver Transplantation Adefovir Dipivoxil Recurrent Hepatitis Standard Liver Volume 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Japan 2004

Authors and Affiliations

  • Yasuhiko Sugawara
    • 1
  • Masatoshi Makuuchi
    • 1
  1. 1.Department of SurgeryGraduate School of Medicine, University of TokyoTokyoJapan

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