Randomized Trial of Post-Operative Interferon Therapy After Resection of Hepatitis C Virus-Related Hepatocellular Carcinoma and Long-Term Outcome

  • Shuhei Nishiguchi
  • Shoji Kubo
Conference paper


Background: We first reported that interferon (IFN) prevent hepatocarcinogenesis in patients with chronic active hepatitis C with cirrhosis in 1995. However, even in the patients who achieved sustained viral response, some patients developed hepatocellular carcinoma (HCC). In these patients, IFN therapy decreased the incidence of recurrence after resection of HCC. In this study, we evaluated the effects of post-operative interferon therapy on the recurrence and the survival rate after resection of HCC.


Chronic Active Hepatitis Cumulative Survival Rate Sustained Viral Response Hepatic Arterial Infusion Chemotherapy Histologic Activity Index 
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Copyright information

© Springer Japan 2004

Authors and Affiliations

  • Shuhei Nishiguchi
    • 1
  • Shoji Kubo
    • 2
  1. 1.Department of HepatologyOsaka City UniversityOsakaJapan
  2. 2.Department of Gastroenterological SurgeryOsaka City UniversityOsakaJapan

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