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Management and Treatment of Hepatitis C

  • Leonard B. Seeff
Conference paper

Abstract

Interferon was first used to treat hepatitis C in the mid-1980’s even before the discovery of the hepatitis C virus (HCV). The initial treatment consisted of administering interferon in a dose of 3 million units (MU) three times a week for a period of 6 months. Because of the poor response rate of only 6%, the treatment duration was extended to 12 months in the late 1980’s/early 1990’s. This led to an increase in the rate of response tol2% to 16%. The next important advance came in the early to mid-1990’s with the addition to interferon treatment of the nucleoside analogue, ribavirin, which further increased the response rate to 34% to 42%. Finally, the introduction in early 2000 of the pegylated interferons led to a markedly improved response rate that began to exceed 50% (Figure)
Figure

Milestones in therapy for hepatitis C (IFN=interferon; R=ribavirin; PEG=peginterferon; m=months)

Keywords

Human Immunodeficiency Virus Sustained Virological Response Sustained Virological Response Rate Porphyria Cutanea Tarda Keratoconjunctivitis Sicca 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    National Institutes of Health Consensus Development Conference. Management of Hepatitis C. Hepatology 1997;26:1S–156S (suppl 1).Google Scholar
  2. 2.
    National Institutes of Health Consensus Development Conference. Management of Hepatitis C 2000. Hepatology 2002;36:1S–252S (suppl 1).Google Scholar

Copyright information

© Springer Japan 2004

Authors and Affiliations

  • Leonard B. Seeff
    • 1
  1. 1.National Institute of Diabetes and Digestive and Kidney DiseasesNational Institutes of HealthBethesdaUSA

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