Skip to main content
  • 64 Accesses

Summary

Our experience on the study of IFN receptor and signals associated with the response in the treatment of chronic hepatitis C (CHC) was described.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Uze G, Lutfalla G, Gresser. Genetic transfer of a functional human interferon -a receptor into mouse cells: cloning and expression of its cDNA. Cell 1990;60:225–234.

    Article  PubMed  CAS  Google Scholar 

  2. Novick D, Cohen B, Rubinstein M. The human interferon-a/ß receptor: characterization and molecular cloning. Cell 1994;77:391–400.

    Article  PubMed  CAS  Google Scholar 

  3. Domanski P, Witte M, Kellum M, Rubinstein M, Hackett R, Pitha P, Colamonici OR. Cloning and expression of a long form of the beta subunit of the interferon alpha beta receptor that is required for signaling. J Biol Chem 1995;270:21606–11.

    Article  PubMed  CAS  Google Scholar 

  4. Pfeffer LM, Basu L, Pfeffer SR, Yang CH, Murti A, Russell-Harde D, Croze E. The short form of the interferon alpha/beta receptor chain 2 acts as a dominant negative for type I interferon action. J Biol Chem 1997;272:11002–5.

    Article  PubMed  CAS  Google Scholar 

  5. Mizukoshi E, Kaneko S, Kaji K, Terasaki S, Matsushita E, Muraguchi M, Ohmoto Y, Kobayashi K. Serum levels of soluble interferon Alfa/Beta receptor as an inhibitory factor of interferon in the patients with chronic hepatitis C. Hepatology 1999;30:1325–31.

    Google Scholar 

  6. Han CS, Chen Y, Ezashi T, Roberts RM. Antiviral activities of the soluble extracellular domains of type I interferon receptors. Proc Natl Acad Sci USA 2001;98:6138–43.

    Article  PubMed  CAS  Google Scholar 

  7. Yatsuhashi H, Fujino T, Matsumoto T, Inoue O, Koga M, Yano M. Immunohistochemical analysis of hepatic interferon alpha-beta receptor level: Relationship between receptor expression and response to interferon therapy in patients with chronic hepatitis C. J Hepatol 1999;30:995–1003.

    Article  PubMed  CAS  Google Scholar 

  8. Navarro S, Colamonici OR, Llombart-Bosch A. Immunohistochemical detection of the type I interferon receptor in human fetal, adult, and neoplastic tissues. Mod Pathol 1996;9:150–156.

    PubMed  CAS  Google Scholar 

  9. Volpes R, van den Oord JJ, De Vos R, Depla E, De Ley M, Desmet VJ. Expression of interferon-gamma receptor in normal and pathological human liver tissue. J Hepatol 1991;12:195–202.

    Article  PubMed  CAS  Google Scholar 

  10. Ishimura N, Fukuda R, Fukumoto S. Relationship between intrahepatic expression of interferon-a receptor mRNA and the histological progress of hepatitis C virus-associated chronic liver diseases. J Gastroenterol Hepatol 1996;11:712–717.

    Article  PubMed  CAS  Google Scholar 

  11. Miyajima I, Sata M, Gondo K, Suzuki H, Tanigawa K. Interferon accumulation in cirrhotic rat liver. J Vir Hepat 1996;3:23–27.

    Article  CAS  Google Scholar 

  12. David M. Signal transduction by type I interferons. Biotechniques 2002;Suppl:58–65.

    Google Scholar 

  13. Borden EC. Gene regulation and clinical roles for interferons in neoplastic diseases. Oncologist 1998;3:198–203.

    PubMed  CAS  Google Scholar 

  14. Harada H, Taniguchi T, Tanaka N. The role of interferon regulatory factors in the interferon system and cell growth control. Biochimie 1998;80:641–50.

    Article  PubMed  CAS  Google Scholar 

  15. Kalvakolanu DV. Virus interception of cytokine-regulated pathways. Trends Microbiol 1999;7:166–71.

    Article  PubMed  CAS  Google Scholar 

  16. Yasukawa H, Misawa H, Sakamoto H, Masuhara M, Sasaki A, Wakioka T, Ohtsuka S, Imaizumi T, Matsuda T, Ihle JN, Yoshimura A. The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop. EMBO J 1999;18:1309–20.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2004 Springer Japan

About this paper

Cite this paper

Yatsuhashi, H. (2004). IFN Receptor and IFN Signals. In: Omata, M., Okita, K. (eds) Therapy for Viral Hepatitis and Prevention of Hepatocellular Carcinoma. Springer, Tokyo. https://doi.org/10.1007/978-4-431-53977-3_17

Download citation

  • DOI: https://doi.org/10.1007/978-4-431-53977-3_17

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-67975-2

  • Online ISBN: 978-4-431-53977-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics