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Hepatitis C: Development of a Ribavirin Liver-Targeting Prodrug

  • Johnson Y. N. Lau
Conference paper

Abstract

Background:The current recommended treatment for chronic hepatitis C virus infection is a combination of interferon and oral ribavirin. Ribavirin treatment is associated with hemolytic anemia, a dose-limiting side-effect.

Result: Viramidine, a liver-targeting prodrug of ribavirin by design, was tested for its pharmacokinetic parameters and safety in animals and humans. Viramidine yielded higher liver drug levels and had superior liver-targeting properties than ribavirin in animal studies. Viramidine gave lowered plasma and red blood cell drug levels of both parent and its ribavirin metabolites when administered at the sane oral dose. In a phase I study, a dose of up to 1,600 mg daily orally for 4 weeks was administered and clinically tolerated in patients with chronic hepatitis C. A phase II study is currently ongoing.

Keywords

Chronic Hepatitis Hemolytic Anemia Adenosine Deaminase Current Recommended Treatment Serum Alanine Aminotransferase Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer Japan 2004

Authors and Affiliations

  • Johnson Y. N. Lau
    • 1
  1. 1.Ribapharm IncCosta MesaUSA

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