Traumatic and Ischemic Hyperthermia

  • Nariyuki Hayashi
  • Dalton W. Dietrich


In contras t to hypothermia, period s of acute or delayed hyperthermia (>39°C) have been reported to worsen outcome in various animal models of brain injury [1,2,4, 5, 6]. Clinical data indicate that periods of core and brain hyperthermia occur in head-injured patients [3,8,9,11]. Many head-injured patients experience fever [10], and recent data indicate that bladder temperature and rectal temperature often underrepresent brain temperature after traumatic brain injury, particularly when the patient is hypo- or hyperthermic [7,9]. In an experimental study, artificially elevating brain temperature in rats to 39°C for a 3-h period 24h after moderate parasagittal F-P injury increased mortality when compared with normothermic rats [6]. Delayed hyperthermia also significantly increased contusion volume and increased the frequency of myelinated axons of abnormal appearance and inflammatory cells. Thus, delayed elevations in brain temperature may represent a clinically import ant secondary injury mechanism. In the clinical setting, especially following severe brain trauma, fever should be aggressively treated.


Traumatic Brain Injury Brain Temperature Critical Head Injury Hypothermia Treatment Head Injury Patient 
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Copyright information

© Springer Japan 2004

Authors and Affiliations

  • Nariyuki Hayashi
    • 1
    • 2
  • Dalton W. Dietrich
    • 3
    • 4
  1. 1.Nihon University Emergency Medical CenterTokyoJapan
  2. 2.Department of Emergency and Critical Care MedicineNihon University School of MedicineTokyoJapan
  3. 3.Department of Neurological Surgery, Neurology and Cell Biology and AnatomyUniversity of Miami School of MedicineMiamiUSA
  4. 4.The Miami Project to Cure ParalysisMiamiUSA

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