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Behavioral Improvements with Posttraumatic Hypothermia

  • Nariyuki Hayashi
  • Dalton W. Dietrich

Abstract

The histopathological assessment of the injured brain is considered to be an important endpoint for evaluating neuroprotective strategies. Nevertheless, from a clinical perspective, it is critical to determine whether histopathological protection correlates with improved functional and behavioral performance. Clifton and colleagues [4] first reported that posttraumatic hypothermia (30° and 33°C) improved beam balance and beam walking tasks compared to normothermic rats (38°C) after midline F-P brain injury (2.10–2.25 atm). Subsequent studies using the F-P model demonstrated that posttraumatic hypothermia (30°C/3h) improved both sensorimotor and cognitive behavioral deficits compared to normothermic rats [2,14].In one study, the protective effect of hypothermia was not seen if the onset of hypothermia was delayed by 30min [14]. In a cortical impact model, postischemic hypothermia treatment improved beam balance and spatial memory performance [6]. Cognitive deficits including memory impairments are commonly observed in humans suffering brain injury.

Keywords

Traumatic Brain Injury Spinal Cord Injury Therapeutic Hypothermia Mild Hypothermia Spinal Cord Ischemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Japan 2004

Authors and Affiliations

  • Nariyuki Hayashi
    • 1
    • 2
  • Dalton W. Dietrich
    • 3
    • 4
  1. 1.Nihon University Emergency Medical CenterTokyoJapan
  2. 2.Department of Emergency and Critical Care MedicineNihon University School of MedicineTokyoJapan
  3. 3.Department of Neurological Surgery, Neurology and Cell Biology and AnatomyUniversity of Miami School of MedicineMiamiUSA
  4. 4.The Miami Project to Cure ParalysisMiamiUSA

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