Skip to main content
SpringerLink
Log in

Behavioral Improvements with Posttraumatic Hypothermia

  • Chapter
Book cover Brain Hypothermia Treatment

  • 114 Accesses

Abstract

The histopathological assessment of the injured brain is considered to be an important endpoint for evaluating neuroprotective strategies. Nevertheless, from a clinical perspective, it is critical to determine whether histopathological protection correlates with improved functional and behavioral performance. Clifton and colleagues [4] first reported that posttraumatic hypothermia (30° and 33°C) improved beam balance and beam walking tasks compared to normothermic rats (38°C) after midline F-P brain injury (2.10–2.25 atm). Subsequent studies using the F-P model demonstrated that posttraumatic hypothermia (30°C/3h) improved both sensorimotor and cognitive behavioral deficits compared to normothermic rats [2,14].In one study, the protective effect of hypothermia was not seen if the onset of hypothermia was delayed by 30min [14]. In a cortical impact model, postischemic hypothermia treatment improved beam balance and spatial memory performance [6]. Cognitive deficits including memory impairments are commonly observed in humans suffering brain injury.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Albin MS, White RJ, Locke GE (1965) Treatment of spinal cord trauma by selective hypothermic perfusion. Surg Forum 16:423–424

    PubMed  CAS  Google Scholar 

  2. Bramlett H, Green EJ, Dietrich WD, Busto R, Globus MY-T, Ginsberg MD (1995) Post-traumatic brain hypothermia provides protection from sensorimotor and cognitive behavioral deficits. J Neurotrauma 12:289–298

    Article  PubMed  CAS  Google Scholar 

  3. Clifton GL (1995) Systemic hypothermia in treatment of severe brain injury: a review and update. J Neurotrauma 12:923–927

    Article  PubMed  CAS  Google Scholar 

  4. Clifton G, Jiang JY, Lyeth BG, et al (1991) Marked protection by moderate hypothermia after experimental traumatic brain injury. J Cereb Blood Flow Metals 11:114–121

    Article  CAS  Google Scholar 

  5. Clifton GL, Miller ER, Choi SC, Levin HS, McCauley S, Smith KR Jr, Muizelaar JP, Wagner FC, Marion DW, Luerssen TG, Chesnut RM, Schwartz M (2001) Lack of effect of induction of hypothermia after acute brain injury. N Eng J Med 344:556–563

    Article  CAS  Google Scholar 

  6. Dixon CE, Markgraf CG, Angileri F, Pike BP, Wolfson B, Newcomb JK, Bismar MM, Blanco AJ, Clifton GL, Hayes RL (1998) Protective effects of moderate hypothermia on behavioral deficits but not necrotic cavitation following cortical impact injury in the rat. J Neurotrauma 15: 95–103

    Article  PubMed  CAS  Google Scholar 

  7. Green BA, Khan T, Raimondi AJ (1973) Local hypothermia as treatment of experimentally induced spinal cord contusion: quantitative analysis of beneficent effect. Surg Forum 24:436–438

    PubMed  CAS  Google Scholar 

  8. Hansebout RR, Kuehner EF, Romero-Sierra C (1976) Effects of local hypothermia and of steroids upon recovery from experimental spinal cord compression injury. Surg Neurol 6:243–246

    Google Scholar 

  9. Herold JA, Kron IL, Langenburg SE, Blackbourne LH, Tribble CG (1994) Complete prevention of postischemic spinal cord injury by means of regional infusion with hypothermic saline and adenosine. J Thorac Cardiovasc Surg 107:536–541

    PubMed  CAS  Google Scholar 

  10. Jiang J-Y, Yu M-K, Zhu C (2000) Effect of long-term hypothermia therapy in patients with severe traumatic brain injury: 1-year follow-up review of 87 cases. J Neurosurg 93:546–549

    Article  PubMed  CAS  Google Scholar 

  11. Kakinohama M, Taira Y, Marsala M (1999) The effect of graded postischemic spinal cord hypothermia on neurological outcome and histopathology after transient spinal ischemia in rat. Anesthesiology 90:789–798

    Article  Google Scholar 

  12. Karibe H, Chen J, Zarow GJ, Graham SH, Weinstein PR (1994) Delayed induction of mild hypothermia to reduce infarct volume after temporary middle cerebral artery occlusion in rats. J Neurosurg 80:112–119

    Article  PubMed  CAS  Google Scholar 

  13. Kuchnor EF, Hansebout RR (1976) Combined steroid and hypothermia treatment of experimental spinal cord injury. Surg Neurol 7:371–376

    Google Scholar 

  14. Lyeth BG, Jiang JY, Shanliang L (1993) Behavioral protection by moderate hypothermia initiated after experimental traumatic brain injury. J Neurotrauma 10:57–64

    Article  PubMed  CAS  Google Scholar 

  15. Marion DW, Obrist WD, Carlier PM, Penrod LE, Darby JM (1993) The use of moderate therapeutic hypothermia for patients with severe head injuries: a preliminary report. J Neurosurg 79:354–362

    Article  PubMed  CAS  Google Scholar 

  16. Marion DW, Penrod LE, Kelsey SF, Obrist WD, Kochanek PM, Palmer AM, Wisniewki SR, DeKosky ST (1997) Treatment of traumatic brain injury with moderate hypothermia. N Eng J Med 336:540–546

    Article  CAS  Google Scholar 

  17. Marsala M, Vanicky I, Yaksh TL (1994) Effect of graded hypothermia (27°–-34°C) on behavioral function, histopathology, and spinal cord blood flow after spinal ischemia in rat. Stroke 25:2038–2046

    Article  PubMed  CAS  Google Scholar 

  18. Marsala M, Galik J, Ishikawa T, Yaksh TL (1997) Technique of selective spinal cord cooling in rat: methodology and application. J Neurosci Methods 74:97–106

    Article  PubMed  CAS  Google Scholar 

  19. Martinez-Arizala A, Green BA (1992) Hypothermia in spinal cord injury. J Neurotrauma 9:S497–S505

    PubMed  Google Scholar 

  20. Matsumoto M, Iida Y, Sakabe T, Sano T, Ishikawa T, Nakakimura K (1997) Mild and moderate hypothermia provide better protection than a burst-suppression dose of thiopental against ischemic spinal cord injury in rabbits. Anesthesiology 86:1120–1127

    Article  PubMed  CAS  Google Scholar 

  21. Resnick DK, Marion DW,Darby JM (1994) The effect of hypothermia on the incidence of delayed traumatic intra cerebral hemorrhage. J Neurosurg 34:252–256

    Article  CAS  Google Scholar 

  22. Robertson CS, Folz R, Grossman RG, Goodman JC (1986) Protection against experimental ischemic spinal cord injury. J Neurosurg 64:633–642

    Article  PubMed  CAS  Google Scholar 

  23. Shiozaki T, Sugimoto H, Taneda M, Yoshida H, Iwai A, Yoshioka T, Sugimoto T (1993) Effect of mild hypothermia on uncontrollable intracranial hypertension after severe head injury. J Neurosurg 79:363–368

    Article  PubMed  CAS  Google Scholar 

  24. Shiozaki T, Sugimoto H, Taneda M, Oda J, Tanaka H, Hiraide A, Shimazu T (1998) Selection of severely head injured patients for mild hypothermia therapy. J Neurosurg 89:206–211

    Article  PubMed  CAS  Google Scholar 

  25. Shiozaki T, Hayakata T, Taneda M, Nakajima Y, Hashiguchi N, Fujimi S, Nakamori Y,Tanaka H, Shimazu T, Sugimoto H, Mild hypothermia study group in Japan (2001) A multi center prospective randomized controlled trial of the efficacy of mild hypothermia for severely head injured patients with low intracranial pressure. J Neurosurg 94:50–54

    Article  PubMed  CAS  Google Scholar 

  26. Svensson LG (1999) An approach to spinal cord protection during descending or thoracoabdominal aortic repairs. Ann Thorac 67:1935–1936

    Article  CAS  Google Scholar 

  27. Tator CH, Deecke L (1973) Value of normothermic perfusion, hypothermic perfusion, and durotomy in the treatment of experimental acute spinal cord trauma. J Neurosurg 39:52–64

    Article  PubMed  CAS  Google Scholar 

  28. Vanicky I, Marsala M, Galik J, Marsala J (1993) Epidural perfusion cooling protection against protracted spinal cord ischemia in rabbits. J Neurosurg 79:736–741

    Article  PubMed  CAS  Google Scholar 

  29. Wells JD, Hansebout RR (1978) Local hypothermia in experimental spinal cord trauma. Surg Neurol 10:200–204

    PubMed  CAS  Google Scholar 

  30. Yu CG, Marcillo AE, Dietrich WD, Fairbanks CA, Wilcox GL, Yezierski RP (1999) Beneficial effects of hypothermia and/or agmatine on locomotor outcome following contusion spinal cord injury. Soc Neurosci Abstr 29:268

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Nihon University Emergency Medical Center, 30-1 Oyaguchi-kamicho, Itabashi-ku, Tokyo, 173-8610, Japan

    Nariyuki Hayashi M.D., Ph.D. (Chair, Professor)

  2. Department of Emergency and Critical Care Medicine, Nihon University School of Medicine, 30-1 Oyaguchi-kamicho, Itabashi-ku, Tokyo, 173-8610, Japan

    Nariyuki Hayashi M.D., Ph.D. (Chair, Professor)

  3. Department of Neurological Surgery, Neurology and Cell Biology and Anatomy, University of Miami School of Medicine, 17641SW 75 Ave., Miami, Florida, 33157, USA

    Dalton W. Dietrich Ph.D. (Distinguished Chair in Neurosurgery, Kinetic Concepts Professor, Scientific Director)

  4. The Miami Project to Cure Paralysis, 1095NW 14th Terrace (R-48), Miami, Florida, 33136, USA

    Dalton W. Dietrich Ph.D. (Distinguished Chair in Neurosurgery, Kinetic Concepts Professor, Scientific Director)

Authors
  1. Nariyuki Hayashi M.D., Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Dalton W. Dietrich Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 2004 Springer Japan

About this chapter

Cite this chapter

Hayashi, N., Dietrich, D.W. (2004). Behavioral Improvements with Posttraumatic Hypothermia. In: Brain Hypothermia Treatment. Springer, Tokyo. https://doi.org/10.1007/978-4-431-53953-7_7

Download citation

  • DOI: https://doi.org/10.1007/978-4-431-53953-7_7

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-67964-6

  • Online ISBN: 978-4-431-53953-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation