Behavioral Improvements with Posttraumatic Hypothermia
The histopathological assessment of the injured brain is considered to be an important endpoint for evaluating neuroprotective strategies. Nevertheless, from a clinical perspective, it is critical to determine whether histopathological protection correlates with improved functional and behavioral performance. Clifton and colleagues  first reported that posttraumatic hypothermia (30° and 33°C) improved beam balance and beam walking tasks compared to normothermic rats (38°C) after midline F-P brain injury (2.10–2.25 atm). Subsequent studies using the F-P model demonstrated that posttraumatic hypothermia (30°C/3h) improved both sensorimotor and cognitive behavioral deficits compared to normothermic rats [2,14].In one study, the protective effect of hypothermia was not seen if the onset of hypothermia was delayed by 30min . In a cortical impact model, postischemic hypothermia treatment improved beam balance and spatial memory performance . Cognitive deficits including memory impairments are commonly observed in humans suffering brain injury.
KeywordsTraumatic Brain Injury Spinal Cord Injury Therapeutic Hypothermia Mild Hypothermia Spinal Cord Ischemia
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