Closing Remarks

  • Nariyuki Hayashi
  • Dalton W. Dietrich


For a long time, the management targets for treatment of severe brain injury have been misunderstood. There is no doubt of the effectiveness of hypothermia treatment for ischemic brain insults in animal studies, as described in chapter 1. However, in clinical studies, the effects of hypothermia were dissimilar to those observed in previous animal studies. Essentially, the results of hypothermia treatment in experimental animal studies and in clinical results are different. The reason for this difference is very simple: the brain injury mechanisms in experimental animal models and in severely traumatized brain-injured patients are different.


Brain Edema Critical Path Severe Traumatic Brain Injury Free Radical Reaction Severe Brain Injury 

Copyright information

© Springer Japan 2004

Authors and Affiliations

  • Nariyuki Hayashi
    • 1
    • 2
  • Dalton W. Dietrich
    • 3
    • 4
  1. 1.Nihon University Emergency Medical CenterTokyoJapan
  2. 2.Department of Emergency and Critical Care MedicineNihon University School of MedicineTokyoJapan
  3. 3.Department of Neurological Surgery, Neurology and Cell Biology and AnatomyUniversity of Miami School of MedicineMiamiUSA
  4. 4.The Miami Project to Cure ParalysisMiamiUSA

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