Indications and Criteria for Dopamine Replacement Therapy
In severely brain-injured patients such as those with a Glasgow Coma Scale score (GCS) less than 5, unconsciousness does not lead to recovery soon after brain hypothermia treatment. Patients that open their eyes with external stimulation, offer no emotional response, and show no understanding of verbal stimulation have poor prognosis . Vegetative patients require dopamine replacement therapy. The indications for dopamine replacement therapy are:
Expressive response around eye and mouth after tapping stimulation
Low cerebrospinal fluid (CSF) dopamine level
Response of CSF dopamine/prolactin ratio to treatment
KeywordsVegetative State Glasgow Coma Scale Score External Stimulation Cerebral Microcirculation Dopamine Replacement Therapy
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© Springer Japan 2004