Diagnosis of Reversibility of the Vegetative State

  • Nariyuki Hayashi
  • Dalton W. Dietrich


The dopamine A10 nervous system is a major part of the emotional center [1,6]. Therefore, emotional stimulation by live music therapy could release dopamine from the hypothalamus A10 nervous system and also suppress the pituitary function. This physiological reaction can be monitored by the increased cerebrospinal fluid (CSF) dopamine and reduced CSF prolactin as signs of an active dopamine A10 nervous system (Fig. 103). No observation of increasing CSF dopamine/prolactin ratio suggests no function of the hypothalamus dopamine A10 nervous system. We have studied the reliability of this diagnostic method for the evaluation of the dopamine A10 nervous function. The monitoring of CSF dopamine/prolactin ratio was very useful to determine the responsiveness of the dopamine A10 nervous system (Fig. 103). As a very impressive sign of the effect of emotional music stimulation on the vegetative patient, increased CSF dopamine/prolactin ratio was more sensitive when the patient was held rather than just listening to the music.


Music Therapy Pituitary Function Severe Brain Injury Brain Injured Patient Severe Head Trauma 
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Copyright information

© Springer Japan 2004

Authors and Affiliations

  • Nariyuki Hayashi
    • 1
    • 2
  • Dalton W. Dietrich
    • 3
    • 4
  1. 1.Nihon University Emergency Medical CenterTokyoJapan
  2. 2.Department of Emergency and Critical Care MedicineNihon University School of MedicineTokyoJapan
  3. 3.Department of Neurological Surgery, Neurology and Cell Biology and AnatomyUniversity of Miami School of MedicineMiamiUSA
  4. 4.The Miami Project to Cure ParalysisMiamiUSA

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