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Traumatic Brain Injury

  • Nariyuki Hayashi
  • Dalton W. Dietrich

Abstract

Quantitative strategies have been developed to evaluate the effects of posttraumatic temperature on patterns of neuronal vulnerability in models of traumatic brain injury (TBI) (Table 1). In a model of parasagittal fluidpercussion (F-P) brain injury in which brain temperature was selectively reduced (30°C) for 3 h starting 5 min after TBI, posttraumatic hypothermia (30°C) significantly decreased contusion volume and reduced the frequency of damaged cortical neurons [5]. In a controlled cortical impact model in rats, mild hypothermia (32°–33°C) initiated 30min before trauma and continued for 2 h decreased contusion volume at 14 days [2, 8]. In a model of diffuse TBI coupled with hypoxia and hypotension, Yamamoto and colleagues [9] reported that moderate hypothermia (30°C) initiated 15 min after injury and maintained for 60 min provided almost complete protection against secondary insults. In contrast, posttraumatic hypothemia (32°C/2 h) failed to reduce volumes of necrotic tissue cavitation after cortical impact injury [6].

Keywords

Traumatic Brain Injury Mild Hypothermia Cereb Blood Flow Moderate Hypothermia Control Cortical Impact 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Bramlett HM, Dietrich WD, Green EJ, Busto R (1997) Chronic histopathological consequences of fluid-percussion brain injury: effects of posttraumatic hypothermia. Acta Neuropath 93:190–199PubMedCrossRefGoogle Scholar
  2. 2.
    Clark RSB, Kochanek PM, Marion DW, Schiding JK, White M, Palmer AM, DeKosky ST (1996) Mild posttraumatic hypothermia reduces mortality after severe controlled cortical impact in rats. J Cereb Blood Flow Metab 16:253–261PubMedCrossRefGoogle Scholar
  3. 3.
    Colbourne F, Sutherland G, Corbett D (1997) Postischemic hypothermia. A critical appraisal with implications for clinical treatment. Molec NeurobioI14:171–201CrossRefGoogle Scholar
  4. 4.
    Dietrich WD, Busto R, Globus MY-T, Ginsberg MD (1993) Intraischemic but not postischemic brain hypothermia protects chronically following forebrain ischemia in rats. J Cereb Blood Flow Metab 13:541–549PubMedCrossRefGoogle Scholar
  5. 5.
    Dietrich WD, Alonso O, Busto R, Globus MY-T, Ginsberg MD (1994) Post-traumatic brain hypothermia reduces histopathological damage following contusive brain injury in the rat. Acta Neuropathol 87:250–258PubMedCrossRefGoogle Scholar
  6. 6.
    Dixon CE, Markgraf CG, Angileri F, Pike BP, Wolfson B, Newcomb JK, Bismar MM, Blanco AJ, Clifton GL, Hayes RL (1998) Protective effects of moderate hypothermia on behavioral deficits but not necrotic cavitation following cortical impact injury in the rat. J Neurotrauma 15:95–103PubMedCrossRefGoogle Scholar
  7. 7.
    Markgraf CG, Glifton GL, Moody MR (2001) Treatment window for hypothermia in brain injury. J Neurosurg 95:979–983PubMedCrossRefGoogle Scholar
  8. 8.
    Palmer AM, Marion DW, Botsceller ML, Redd EE (1993) Therapeutic hypothermia is cytoprotective without attenuating the traumatic brain injury-induced elevations in interstitial concentrations of aspartate and glutamate. J Neurotrauma 10:363–372PubMedCrossRefGoogle Scholar
  9. 9.
    Smith DG, Chen X-H, Pierce ES, McIntosh TK (1997) Progressive atrophy and neuronal death for one year following brain trauma in the rat. J Neurotrauma 14:715–727PubMedCrossRefGoogle Scholar
  10. 10.
    Yamamoto M, Marmarou CR, Stiefel MF, Beaumont A, Marmarou A (1999) Neuroprotective effect of hypothermia on neuronal injury in diffuse traumatic brain injury coupled with hypoxia and hypotension. J Neurotrauma 16:487–500PubMedCrossRefGoogle Scholar

Copyright information

© Springer Japan 2004

Authors and Affiliations

  • Nariyuki Hayashi
    • 1
    • 2
  • Dalton W. Dietrich
    • 3
    • 4
  1. 1.Nihon University Emergency Medical CenterTokyoJapan
  2. 2.Department of Emergency and Critical Care MedicineNihon University School of MedicineTokyoJapan
  3. 3.Department of Neurological Surgery, Neurology and Cell Biology and AnatomyUniversity of Miami School of MedicineMiamiUSA
  4. 4.The Miami Project to Cure ParalysisMiamiUSA

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