Traumatic Brain Injury

  • Nariyuki Hayashi
  • Dalton W. Dietrich


Quantitative strategies have been developed to evaluate the effects of posttraumatic temperature on patterns of neuronal vulnerability in models of traumatic brain injury (TBI) (Table 1). In a model of parasagittal fluidpercussion (F-P) brain injury in which brain temperature was selectively reduced (30°C) for 3 h starting 5 min after TBI, posttraumatic hypothermia (30°C) significantly decreased contusion volume and reduced the frequency of damaged cortical neurons [5]. In a controlled cortical impact model in rats, mild hypothermia (32°–33°C) initiated 30min before trauma and continued for 2 h decreased contusion volume at 14 days [2, 8]. In a model of diffuse TBI coupled with hypoxia and hypotension, Yamamoto and colleagues [9] reported that moderate hypothermia (30°C) initiated 15 min after injury and maintained for 60 min provided almost complete protection against secondary insults. In contrast, posttraumatic hypothemia (32°C/2 h) failed to reduce volumes of necrotic tissue cavitation after cortical impact injury [6].


Traumatic Brain Injury Mild Hypothermia Cereb Blood Flow Moderate Hypothermia Control Cortical Impact 
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Copyright information

© Springer Japan 2004

Authors and Affiliations

  • Nariyuki Hayashi
    • 1
    • 2
  • Dalton W. Dietrich
    • 3
    • 4
  1. 1.Nihon University Emergency Medical CenterTokyoJapan
  2. 2.Department of Emergency and Critical Care MedicineNihon University School of MedicineTokyoJapan
  3. 3.Department of Neurological Surgery, Neurology and Cell Biology and AnatomyUniversity of Miami School of MedicineMiamiUSA
  4. 4.The Miami Project to Cure ParalysisMiamiUSA

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