Abstract
Quantitative strategies have been developed to evaluate the effects of posttraumatic temperature on patterns of neuronal vulnerability in models of traumatic brain injury (TBI) (Table 1). In a model of parasagittal fluidpercussion (F-P) brain injury in which brain temperature was selectively reduced (30°C) for 3 h starting 5 min after TBI, posttraumatic hypothermia (30°C) significantly decreased contusion volume and reduced the frequency of damaged cortical neurons [5]. In a controlled cortical impact model in rats, mild hypothermia (32°–33°C) initiated 30min before trauma and continued for 2 h decreased contusion volume at 14 days [2, 8]. In a model of diffuse TBI coupled with hypoxia and hypotension, Yamamoto and colleagues [9] reported that moderate hypothermia (30°C) initiated 15 min after injury and maintained for 60 min provided almost complete protection against secondary insults. In contrast, posttraumatic hypothemia (32°C/2 h) failed to reduce volumes of necrotic tissue cavitation after cortical impact injury [6].
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© 2004 Springer Japan
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Hayashi, N., Dietrich, D.W. (2004). Traumatic Brain Injury. In: Brain Hypothermia Treatment. Springer, Tokyo. https://doi.org/10.1007/978-4-431-53953-7_5
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DOI: https://doi.org/10.1007/978-4-431-53953-7_5
Publisher Name: Springer, Tokyo
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