Prolonged Anesthesia for Brain Hypothermia Treatment in ICU

  • Nariyuki Hayashi
  • Dalton W. Dietrich


The effects of analgesic agents and mucle relaxants on intracranial pressure (ICP), cerebral blood flow (CBF), and blood pressure are listed in Table 13. Short duration of brain hypothermia, such as 48 h, is ineffective in preventing brain edema and can make the overall condition much worse [3]. In treatment of severe brain injury, short duration of moderate brain hypothermia (34°C) does not allow recovery and only halts the progression of neuronal damage and pathophysiology. In this case, rewarming can worsen the outcome because of reprogression of secondary brain damage and overlapping rewarming stress. This means that recovery of injured brain tissue or at least part-recovery are criteria to commence rewarming. Therefore, in severely brain-injured patients, prolonged brain hypothermia is required.


Cerebral Blood Flow Analgesic Agent Severe Brain Injury Brain Injured Patient Cardiopulmonary Function 
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Copyright information

© Springer Japan 2004

Authors and Affiliations

  • Nariyuki Hayashi
    • 1
    • 2
  • Dalton W. Dietrich
    • 3
    • 4
  1. 1.Nihon University Emergency Medical CenterTokyoJapan
  2. 2.Department of Emergency and Critical Care MedicineNihon University School of MedicineTokyoJapan
  3. 3.Department of Neurological Surgery, Neurology and Cell Biology and AnatomyUniversity of Miami School of MedicineMiamiUSA
  4. 4.The Miami Project to Cure ParalysisMiamiUSA

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