The Importance of Chronic Outcome Measures in Assessing Neuroprotective Strategies

  • Nariyuki Hayashi
  • Dalton W. Dietrich


Although cooling during the ischemic period provides chronic histopathological and behavioral protection, the issue of whether long-lasting protection occurs with postischemic hypothermia has been raised [4,5]. A lack of chronic protection with postischemic hypothermia was first reported after transient global ischemia [5] in which case significant CA1 hippocampal protection was seen at postischemic day three but not at 2 months. A failure of postischemic hypothermia to provide chronic protection using behavioral strategies was also subsequently reported [11]. These data emphasized the important point that chronic outcome measures should be used to assess neuroprotective procedures or pharmacological agents prior to the initiation of clinical trials.


Cereb Blood Flow Forebrain Ischemia Carotid Artery Occlusion Transient Global Ischemia Postischemic Brain 
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Copyright information

© Springer Japan 2004

Authors and Affiliations

  • Nariyuki Hayashi
    • 1
    • 2
  • Dalton W. Dietrich
    • 3
    • 4
  1. 1.Nihon University Emergency Medical CenterTokyoJapan
  2. 2.Department of Emergency and Critical Care MedicineNihon University School of MedicineTokyoJapan
  3. 3.Department of Neurological Surgery, Neurology and Cell Biology and AnatomyUniversity of Miami School of MedicineMiamiUSA
  4. 4.The Miami Project to Cure ParalysisMiamiUSA

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