Concepts in Brain Tissue Temperature Control

  • Nariyuki Hayashi
  • Dalton W. Dietrich


The basic concept of brain hypothermia treatment is the management of adequate cerebral oxygenation, administration of sufficient metabolic substrates for injured neurons, control of neurohormonal function, and stabilization of cardiopulmonary function [4,6]. The previous concept of neuroprotection to tolerate brain ischemia by reduced brain metabolism makes it difficult for dying neurons in injured brain tissue to make a recovery. Therefore, stable systemic circulation and metabolism are important initially. In severely brain-injured patients, cardiopulmonary dysfunction occurs because of stress associated with the excess release of catecholamines [5]. This initial catecholamine surge [1,5] and neurohormonal response of the hypothalamuspituitary- adrenal (HPA) axis [2] produces cardiac dysfunction not only by cardiac ischemia with coronary spasm but also by cardio-myocytolysis with prolonged contraction of cardiac muscles. To prevent this cardiopulmonary dysfunction, control of catecholamine surge by early induction of brain hypothermia is very useful [4,6].


Brain Edema Brain Damage Serum Glucose Level Metabolic Shift Intermittent Control 
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Copyright information

© Springer Japan 2004

Authors and Affiliations

  • Nariyuki Hayashi
    • 1
    • 2
  • Dalton W. Dietrich
    • 3
    • 4
  1. 1.Nihon University Emergency Medical CenterTokyoJapan
  2. 2.Department of Emergency and Critical Care MedicineNihon University School of MedicineTokyoJapan
  3. 3.Department of Neurological Surgery, Neurology and Cell Biology and AnatomyUniversity of Miami School of MedicineMiamiUSA
  4. 4.The Miami Project to Cure ParalysisMiamiUSA

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