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Mistakes and Pitfalls of Brain Hypothermia Treatment

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Brain Hypothermia Treatment

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Abstract

To prevent brain edema, early administration of manitol and glycerol were recommended previously [21]. However, brain edema progresses not only as a secondary pathophysiological change [23] of directly injured brain tissue, but also by hypothalamus-pituitary-adrenal (HPA) axis neurohoromonal dysfunction [4,9] such as cardiopulmonary dysfunction caused by catecholamine surge [9], masking brain hypoxia [9], brain thermo-pooling [7,8,12], insulin-resistant hyperglycemia [7,9,12], and vasopressin-related blood-brain barrier (BBB) dysfunction [8,14]. Therefore, prevention of secondary brain damage caused by HPA axis neurohoromonal dysfunction should precede management of brain edema by administration of manitol and glycerol [9].

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Authors and Affiliations

  1. Nihon University Emergency Medical Center, 30-1 Oyaguchi-kamicho, Itabashi-ku, Tokyo, 173-8610, Japan

    Nariyuki Hayashi M.D., Ph.D. (Chair, Professor)

  2. Department of Emergency and Critical Care Medicine, Nihon University School of Medicine, 30-1 Oyaguchi-kamicho, Itabashi-ku, Tokyo, 173-8610, Japan

    Nariyuki Hayashi M.D., Ph.D. (Chair, Professor)

  3. Department of Neurological Surgery, Neurology and Cell Biology and Anatomy, University of Miami School of Medicine, 17641SW 75 Ave., Miami, Florida, 33157, USA

    Dalton W. Dietrich Ph.D. (Distinguished Chair in Neurosurgery, Kinetic Concepts Professor, Scientific Director)

  4. The Miami Project to Cure Paralysis, 1095NW 14th Terrace (R-48), Miami, Florida, 33136, USA

    Dalton W. Dietrich Ph.D. (Distinguished Chair in Neurosurgery, Kinetic Concepts Professor, Scientific Director)

Authors
  1. Nariyuki Hayashi M.D., Ph.D.
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  2. Dalton W. Dietrich Ph.D.
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© 2004 Springer Japan

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Hayashi, N., Dietrich, D.W. (2004). Mistakes and Pitfalls of Brain Hypothermia Treatment. In: Brain Hypothermia Treatment. Springer, Tokyo. https://doi.org/10.1007/978-4-431-53953-7_35

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  • DOI: https://doi.org/10.1007/978-4-431-53953-7_35

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-67964-6

  • Online ISBN: 978-4-431-53953-7

  • eBook Packages: Springer Book Archive

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