Abstract
The state of neuronal damage after severe brain injury may progress with time. Similary, the target of management may also differ within the injury time window in severely brain-injured patients. In addressing this clinical issue, early management is much easier and simpler than delayed induction of hypothermia treatment. Accordingly, the main targets of treatment at early and late stages need to be defined. In some cases, control of brain edema and intracranial pressure (ICP) elevation have been the focus of initial treatment for neuroprotection in severely brain-injured patients [2,11,14]. However, this approach is not correct because brain edema and ICP elevation occur as a result of neuronal hypoxia, adequate metabolic supply to the injured neurons, cerebral blood flow (CBF) disturbances, unsuccessful management of cardiopulmonary dysfunction, and hemoglobin dysfunction [4]. For brain hypothermia management of severe brain injury, the starting time is important and the main target of management will change according to the time after insults and trauma [3,4].
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© 2004 Springer Japan
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Hayashi, N., Dietrich, D.W. (2004). Induction of Brain Hypothermia. In: Brain Hypothermia Treatment. Springer, Tokyo. https://doi.org/10.1007/978-4-431-53953-7_33
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DOI: https://doi.org/10.1007/978-4-431-53953-7_33
Publisher Name: Springer, Tokyo
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