The effectiveness of brain hypothermia for severe brain injury is mainly determined by several factors as shown in Fig. 30 (Chap. 26). Coma with Glasgow Coma Scale (GCS) less than 4, uncontrollable hyperglycemia with serum glucose levels above 230 mg/dl, delayed induction of hypothermia, and low systolic blood pressure are negative factors for the success of brain hypothermia treatment . Coma (GCS > 3), control of serum glucose levels to below 180 mg/dl, induction of brain hypothermia within 3h after insult, and control of systolic blood pressure above 100 mmHg without catecholamines are good indications for the effectiveness of brain hypothermia treatment.