• Nariyuki Hayashi
  • Dalton W. Dietrich


The effectiveness of brain hypothermia for severe brain injury is mainly determined by several factors as shown in Fig. 30 (Chap. 26). Coma with Glasgow Coma Scale (GCS) less than 4, uncontrollable hyperglycemia with serum glucose levels above 230 mg/dl, delayed induction of hypothermia, and low systolic blood pressure are negative factors for the success of brain hypothermia treatment [1]. Coma (GCS > 3), control of serum glucose levels to below 180 mg/dl, induction of brain hypothermia within 3h after insult, and control of systolic blood pressure above 100 mmHg without catecholamines are good indications for the effectiveness of brain hypothermia treatment.


Glasgow Coma Scale Serum Glucose Serum Glucose Level Severe Brain Injury Brain Hypoxia 


  1. 1.
    Hayashi N (2000) The clinical issue and effectiveness of brain hypothermia treatment for severe brain injured patients. In: Hayashi N (ed) Brain hypothermia. Springer, Berlin Heidelberg New York Tokyo, pp 121–151CrossRefGoogle Scholar

Copyright information

© Springer Japan 2004

Authors and Affiliations

  • Nariyuki Hayashi
    • 1
    • 2
  • Dalton W. Dietrich
    • 3
    • 4
  1. 1.Nihon University Emergency Medical CenterTokyoJapan
  2. 2.Department of Emergency and Critical Care MedicineNihon University School of MedicineTokyoJapan
  3. 3.Department of Neurological Surgery, Neurology and Cell Biology and AnatomyUniversity of Miami School of MedicineMiamiUSA
  4. 4.The Miami Project to Cure ParalysisMiamiUSA

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