• Nariyuki Hayashi
  • Dalton W. Dietrich


The prognosis of severe brain damage is decided by several factors such as severity, cause of brain damage, the hypothalamus-pituitary-adrenal (HPA) axis neurohormonal release [1], severity of circulatory metabolic changes [2] associated with catecholamine surge, stress-related hyperglycemia, time after the accident, age, and sex [3,4]. Therefore the indication of hypothermia includes several viewpoints as shown in Table 5 in chapter 29. The contraindications are as follow.


Brain Damage Glasgow Coma Score Serum Glucose Level Hypothermia Treatment Severe Brain Damage 
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    Dudariev VP, Lanovenko II (1999) Changes in the oxygen-binding properties of the blood in white rats under the influence of hypoxia and its pharmacological correction. Fiziol Zh 45:97–103PubMedGoogle Scholar
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    Hayashi N (1997) Prevention of vegetation after severe head trauma and stroke by combination therapy of cerebral hypothermia and activation of immune-dopaminergic nervous system. Proceedings of the 6th annual meeting of Society for Treatment of Coma 6:133–145Google Scholar
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    Hayashi N (2000) The clinical issue and effectiveness of brain hypothermia treatment for severe brain injured patients. In: Hayashi N (ed) Brain hypothermia. Springer, Berlin Heidelberg New York Tokyo, pp 121–151CrossRefGoogle Scholar
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Copyright information

© Springer Japan 2004

Authors and Affiliations

  • Nariyuki Hayashi
    • 1
    • 2
  • Dalton W. Dietrich
    • 3
    • 4
  1. 1.Nihon University Emergency Medical CenterTokyoJapan
  2. 2.Department of Emergency and Critical Care MedicineNihon University School of MedicineTokyoJapan
  3. 3.Department of Neurological Surgery, Neurology and Cell Biology and AnatomyUniversity of Miami School of MedicineMiamiUSA
  4. 4.The Miami Project to Cure ParalysisMiamiUSA

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