Limitations of Postischemic Hypothermia
From a clinical treatment perspective, the question of whether postischemic brain hypothermia can protect the brain is an important one. In 1989, Busto and colleagues  reported that immediate postischemic hypothermia (30°C/3 h) significantly protected the CA1 hippocampus from histopathological injury after 3 days of recirculation. Hypothermia (32°C) after ventricular fibrillation cardiac arrest also reduced overall brain histologic damage [9,10]. Subsequent experiments in which the importance of ischemic duration was addressed  indicated that the degree of protection was reduced with longer ischemic durations or no significant benefit was reported. Animal studies indicate that the therapeutic window for postischemic hypothemia may be narrow and related to ischemic duration and ischemic severity .
KeywordsCereb Blood Flow Forebrain Ischemia Moderate Hypothermia Transient Cerebral Ischemia Ischemic Duration
- 8.Dietrich WD, Busto R, Alonso O, Pita-Loor Y, Globus MY-T, Ginsberg MD (1991) Int raischemic brain hypothermia promotes postischemic metabolic recovery and somatosensory circuit activation. J Cereb Blood Flow Metab 11(Suppl) 11:S854Google Scholar