Limitations of Postischemic Hypothermia

  • Nariyuki Hayashi
  • Dalton W. Dietrich


From a clinical treatment perspective, the question of whether postischemic brain hypothermia can protect the brain is an important one. In 1989, Busto and colleagues [1] reported that immediate postischemic hypothermia (30°C/3 h) significantly protected the CA1 hippocampus from histopathological injury after 3 days of recirculation. Hypothermia (32°C) after ventricular fibrillation cardiac arrest also reduced overall brain histologic damage [9,10]. Subsequent experiments in which the importance of ischemic duration was addressed [4] indicated that the degree of protection was reduced with longer ischemic durations or no significant benefit was reported. Animal studies indicate that the therapeutic window for postischemic hypothemia may be narrow and related to ischemic duration and ischemic severity [5].


Cereb Blood Flow Forebrain Ischemia Moderate Hypothermia Transient Cerebral Ischemia Ischemic Duration 
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Copyright information

© Springer Japan 2004

Authors and Affiliations

  • Nariyuki Hayashi
    • 1
    • 2
  • Dalton W. Dietrich
    • 3
    • 4
  1. 1.Nihon University Emergency Medical CenterTokyoJapan
  2. 2.Department of Emergency and Critical Care MedicineNihon University School of MedicineTokyoJapan
  3. 3.Department of Neurological Surgery, Neurology and Cell Biology and AnatomyUniversity of Miami School of MedicineMiamiUSA
  4. 4.The Miami Project to Cure ParalysisMiamiUSA

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