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New Concept of Brain Hypothermia Treatment

  • Nariyuki Hayashi
  • Dalton W. Dietrich

Abstract

The basic concept of brain hypothermia treatment is the control of brain tissue temperature to between 32° and 34°C, maintenance of systemic circulation- metabolism, neurohormonal control, and stabilization of the immune function, for the restoration of injured neurons [14]. Reduced brain metabolism for neuroprotection from brain ischemia and the prevention of intracranial pressure (ICP) elevation are not initial goals. To restore dying neurons in injured brain tissue, hypothermia itself is not sufficient. Administration of oxygen, stabilization of brain metabolism with adequate metabolic substrates, and prevention of excess neurohormonal reactions of the hypothalamus-pituitaryadrenal (HPA) axis are the initial goals of brain hypothermia [13, 14, 15]. The early induction of mild to moderate brain hypothermia (32–34°C) is very successful in the prevention of hazardous excess neurohormonal reactions of HPA axis. Early anesthesia is also helpful in preventing excess stimulation of the HPA axis [9,10, 14, 15, 16].

Keywords

Brain Edema Brain Damage Severe Brain Injury Excess Release Hypothermia Treatment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Japan 2004

Authors and Affiliations

  • Nariyuki Hayashi
    • 1
    • 2
  • Dalton W. Dietrich
    • 3
    • 4
  1. 1.Nihon University Emergency Medical CenterTokyoJapan
  2. 2.Department of Emergency and Critical Care MedicineNihon University School of MedicineTokyoJapan
  3. 3.Department of Neurological Surgery, Neurology and Cell Biology and AnatomyUniversity of Miami School of MedicineMiamiUSA
  4. 4.The Miami Project to Cure ParalysisMiamiUSA

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