The Target of Treatment of Severe Brain Injury in the Acute Stage

  • Nariyuki Hayashi
  • Dalton W. Dietrich


The target of treatment of brain injury in the acute stage is variable and depends on severity, time after injury, and presence or not of hypothalamus-pituitary-adrenal (HPA) axis neurohormonal reactions. This section focuses on severe brain injury cases that require brain hypothermia treatment. Three major targets of intensive care unit (ICU) management in the acute stage are summarized: neuronal oxygenation and adequate administration of metabolic substrates for injured neurons, management of HPA axis neurohormonal dysfunction, and prevention of selective radical attack of the dopamine A10 nervous system.


Cerebral Blood Flow Brain Edema Oxygen Delivery Cerebral Perfusion Pressure Acute Stage 
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Copyright information

© Springer Japan 2004

Authors and Affiliations

  • Nariyuki Hayashi
    • 1
    • 2
  • Dalton W. Dietrich
    • 3
    • 4
  1. 1.Nihon University Emergency Medical CenterTokyoJapan
  2. 2.Department of Emergency and Critical Care MedicineNihon University School of MedicineTokyoJapan
  3. 3.Department of Neurological Surgery, Neurology and Cell Biology and AnatomyUniversity of Miami School of MedicineMiamiUSA
  4. 4.The Miami Project to Cure ParalysisMiamiUSA

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