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History of Clinical Trials of Hypothermia Treatment of Severe Brain Injury

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Brain Hypothermia Treatment

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Abstract

In 1943, Fay [14] reported the positive effect of hypothermia for brain trauma. However, the patient number was few and scientific data of effective hypothermia were not presented. In 1954, Rosomoff [32,35] measured the changes in cerebral blood flow (CBF) during hypothermia treatment and initiated clinical trials of the procedure. Subsequently, many clinical trials of hypothermia have been undertaken over a period of decades, and deep global hypothermia has been established as a principal cerebral protective technique for circulatory arrest procedures [1,2,28,37]. Hypothermia anesthesia was only successful for the prevention of brain damage during surgical accidents or in cases of temporary circulatory arrest. The classical mechanism proposed for the neuronal protection afforded by hypothermia is a reduction of oxygen and glucose consumption caused by lowering the rates of enzymatic reactions and metabolism. Brain hypothermia has thus been recommended to effect neuronal protection during anesthesia [2,28].

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Authors and Affiliations

  1. Nihon University Emergency Medical Center, 30-1 Oyaguchi-kamicho, Itabashi-ku, Tokyo, 173-8610, Japan

    Nariyuki Hayashi M.D., Ph.D. (Chair, Professor)

  2. Department of Emergency and Critical Care Medicine, Nihon University School of Medicine, 30-1 Oyaguchi-kamicho, Itabashi-ku, Tokyo, 173-8610, Japan

    Nariyuki Hayashi M.D., Ph.D. (Chair, Professor)

  3. Department of Neurological Surgery, Neurology and Cell Biology and Anatomy, University of Miami School of Medicine, 17641SW 75 Ave., Miami, Florida, 33157, USA

    Dalton W. Dietrich Ph.D. (Distinguished Chair in Neurosurgery, Kinetic Concepts Professor, Scientific Director)

  4. The Miami Project to Cure Paralysis, 1095NW 14th Terrace (R-48), Miami, Florida, 33136, USA

    Dalton W. Dietrich Ph.D. (Distinguished Chair in Neurosurgery, Kinetic Concepts Professor, Scientific Director)

Authors
  1. Nariyuki Hayashi M.D., Ph.D.
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  2. Dalton W. Dietrich Ph.D.
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© 2004 Springer Japan

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Hayashi, N., Dietrich, D.W. (2004). History of Clinical Trials of Hypothermia Treatment of Severe Brain Injury. In: Brain Hypothermia Treatment. Springer, Tokyo. https://doi.org/10.1007/978-4-431-53953-7_23

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  • DOI: https://doi.org/10.1007/978-4-431-53953-7_23

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-67964-6

  • Online ISBN: 978-4-431-53953-7

  • eBook Packages: Springer Book Archive

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