History of Clinical Trials of Hypothermia Treatment of Severe Brain Injury

  • Nariyuki Hayashi
  • Dalton W. Dietrich


In 1943, Fay [14] reported the positive effect of hypothermia for brain trauma. However, the patient number was few and scientific data of effective hypothermia were not presented. In 1954, Rosomoff [32,35] measured the changes in cerebral blood flow (CBF) during hypothermia treatment and initiated clinical trials of the procedure. Subsequently, many clinical trials of hypothermia have been undertaken over a period of decades, and deep global hypothermia has been established as a principal cerebral protective technique for circulatory arrest procedures [1,2,28,37]. Hypothermia anesthesia was only successful for the prevention of brain damage during surgical accidents or in cases of temporary circulatory arrest. The classical mechanism proposed for the neuronal protection afforded by hypothermia is a reduction of oxygen and glucose consumption caused by lowering the rates of enzymatic reactions and metabolism. Brain hypothermia has thus been recommended to effect neuronal protection during anesthesia [2,28].


Therapeutic Hypothermia Moderate Hypothermia Severe Brain Injury Hypothermia Group Hypothermia Treatment 
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Copyright information

© Springer Japan 2004

Authors and Affiliations

  • Nariyuki Hayashi
    • 1
    • 2
  • Dalton W. Dietrich
    • 3
    • 4
  1. 1.Nihon University Emergency Medical CenterTokyoJapan
  2. 2.Department of Emergency and Critical Care MedicineNihon University School of MedicineTokyoJapan
  3. 3.Department of Neurological Surgery, Neurology and Cell Biology and AnatomyUniversity of Miami School of MedicineMiamiUSA
  4. 4.The Miami Project to Cure ParalysisMiamiUSA

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