Summary and Future Directions

  • Nariyuki Hayashi
  • Dalton W. Dietrich


Based on experimental data, mild to moderate hypothermia appears to be one of the most potent therapeutic approaches to treating neurotrauma. Clearly the ability of temperature to target multiple pathophysiological processes may help explain why hypothermia works in multiple trauma models. Nevertheless, the recent findings from the NIH-supported North American multicenter trial on the usage of hypothermia in head injury patients indicates that more work is required to systematically evaluate the beneficial and harmful effects of clinical hypothermia in different populations of injured patients [10]. In brain and spinal cord injury, the advantages of systemic cooling versus focal cooling must also be considered. The continued development of methods of imaging regional temperature gradients in patients should provide a powerful approach to assessing and treating patients.


Traumatic Brain Injury Spinal Cord Injury Moderate Hypothermia Potent Therapeutic Approach Secondary Insult 
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Copyright information

© Springer Japan 2004

Authors and Affiliations

  • Nariyuki Hayashi
    • 1
    • 2
  • Dalton W. Dietrich
    • 3
    • 4
  1. 1.Nihon University Emergency Medical CenterTokyoJapan
  2. 2.Department of Emergency and Critical Care MedicineNihon University School of MedicineTokyoJapan
  3. 3.Department of Neurological Surgery, Neurology and Cell Biology and AnatomyUniversity of Miami School of MedicineMiamiUSA
  4. 4.The Miami Project to Cure ParalysisMiamiUSA

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