Gene Expression and Apoptosis

  • Nariyuki Hayashi
  • Dalton W. Dietrich


Brain and spinal cord trauma have been reported to induce a variety of genes and proteins that would be expected to influence traumatic outcome [6,7,9, 10, 11,15,16,18]. Alterations in posttraumatic temperature may affect the induction of various genes in the injured tissue. Hypothermia was reported to attenuate the normal increase in interleukin-1beta RNA in traumatized rats [8]. In a model of transient global forebrain dischemia, Kamme and colleagues [12] reported that hypothermia altered the expression of specific genes. In regard to postischemic hyperthermia, Kim and colleagues [13] reported in a model of transient middle cerebral artery occlusion that c-fos and hsp70 mRNA expression were increased in heated rats when compared with normothermic animals. Because intraischemic hypothermia can significantly alter protein kinase C activity, temperature-sensitive intracellular mechanisms also participate in neuronal death [2].


Traumatic Brain Injury Nerve Growth Factor Cereb Blood Flow Control Cortical Impact Transient Cerebral Ischemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Japan 2004

Authors and Affiliations

  • Nariyuki Hayashi
    • 1
    • 2
  • Dalton W. Dietrich
    • 3
    • 4
  1. 1.Nihon University Emergency Medical CenterTokyoJapan
  2. 2.Department of Emergency and Critical Care MedicineNihon University School of MedicineTokyoJapan
  3. 3.Department of Neurological Surgery, Neurology and Cell Biology and AnatomyUniversity of Miami School of MedicineMiamiUSA
  4. 4.The Miami Project to Cure ParalysisMiamiUSA

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