Brain and spinal cord trauma have been reported to induce a variety of genes and proteins that would be expected to influence traumatic outcome [6,7,9, 10, 11,15,16,18]. Alterations in posttraumatic temperature may affect the induction of various genes in the injured tissue. Hypothermia was reported to attenuate the normal increase in interleukin-1beta RNA in traumatized rats . In a model of transient global forebrain dischemia, Kamme and colleagues  reported that hypothermia altered the expression of specific genes. In regard to postischemic hyperthermia, Kim and colleagues  reported in a model of transient middle cerebral artery occlusion that c-fos and hsp70 mRNA expression were increased in heated rats when compared with normothermic animals. Because intraischemic hypothermia can significantly alter protein kinase C activity, temperature-sensitive intracellular mechanisms also participate in neuronal death .
KeywordsTraumatic Brain Injury Nerve Growth Factor Cereb Blood Flow Control Cortical Impact Transient Cerebral Ischemia
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