The consequences of brain trauma on local cerebral blood flow (ICBF) have been documented clinically and in several experimental models [1, 2, 3, 4,7]. Perfusion deficits and cerebral ischemia are believed to represent import ant secondary injury mechanisms after traumatic brain injury (TEl) [5,8]. Numerous studies have shown that systemic hypothermia decreased both CBF and CMRO2 . The consequences of early posttraumatic brain hypothermia on lCBF have been investigated after moderate F-P brain injury. Zhao and colleagues  reported that moderate hypothermia (30°C/3h) significantly lowered lCBF 6h after TBI when compared with normothermic animals. As a consequence, a state of mild metabolism-greater-than-blood-flow dissociation was demonstrated.Thus, posttraumatic brain hypothermia does not appear to improve outcome by increasing posttraumatic 1CBF.
KeywordsTraumatic Brain Injury Cerebral Blood Flow Cereb Blood Flow Perfusion Deficit Moderate Hypothermia
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