Cerebral Blood Flow

  • Nariyuki Hayashi
  • Dalton W. Dietrich


The consequences of brain trauma on local cerebral blood flow (ICBF) have been documented clinically and in several experimental models [1, 2, 3, 4,7]. Perfusion deficits and cerebral ischemia are believed to represent import ant secondary injury mechanisms after traumatic brain injury (TEl) [5,8]. Numerous studies have shown that systemic hypothermia decreased both CBF and CMRO2 [6]. The consequences of early posttraumatic brain hypothermia on lCBF have been investigated after moderate F-P brain injury. Zhao and colleagues [9] reported that moderate hypothermia (30°C/3h) significantly lowered lCBF 6h after TBI when compared with normothermic animals. As a consequence, a state of mild metabolism-greater-than-blood-flow dissociation was demonstrated.Thus, posttraumatic brain hypothermia does not appear to improve outcome by increasing posttraumatic 1CBF.


Traumatic Brain Injury Cerebral Blood Flow Cereb Blood Flow Perfusion Deficit Moderate Hypothermia 
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Copyright information

© Springer Japan 2004

Authors and Affiliations

  • Nariyuki Hayashi
    • 1
    • 2
  • Dalton W. Dietrich
    • 3
    • 4
  1. 1.Nihon University Emergency Medical CenterTokyoJapan
  2. 2.Department of Emergency and Critical Care MedicineNihon University School of MedicineTokyoJapan
  3. 3.Department of Neurological Surgery, Neurology and Cell Biology and AnatomyUniversity of Miami School of MedicineMiamiUSA
  4. 4.The Miami Project to Cure ParalysisMiamiUSA

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