Nitric Oxide

  • Nariyuki Hayashi
  • Dalton W. Dietrich


Recent data have implicated the importance of nitric oxide (NO) in the pathophysiology of traumatic brain injury (TEl) [2, 3, 4, 5]. After controlled cortical impact injury, levels of neuronal nitric oxide synthase (nNOS), mRNA, and protein increased by 2h after trauma [3]. Using a moderate F-P model, Wada and colleagues [4] reported the immediate but transient increase in constitutive nitric oxide synthase (cNOS) activity within the histopathologically injured cortical region.This increase in cNOS activity was followed by a sustained reduction in cNOS activity below control levels. Inducible NOS (iNOS) activity was also reported to increase at 7 days after TEl [5]


Nitric Oxide Traumatic Brain Injury Therapeutic Hypothermia cNOS Activity Matic Brain Injury 
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  1. 1.
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    Wada K, Chatzipantelli K, Busto R, Kraydieh S, Dietrich WD (1998) Inducible nitric oxide synthase activation after traumatic brain injury. Neurosurgery 43:1427–1436PubMedGoogle Scholar

Copyright information

© Springer Japan 2004

Authors and Affiliations

  • Nariyuki Hayashi
    • 1
    • 2
  • Dalton W. Dietrich
    • 3
    • 4
  1. 1.Nihon University Emergency Medical CenterTokyoJapan
  2. 2.Department of Emergency and Critical Care MedicineNihon University School of MedicineTokyoJapan
  3. 3.Department of Neurological Surgery, Neurology and Cell Biology and AnatomyUniversity of Miami School of MedicineMiamiUSA
  4. 4.The Miami Project to Cure ParalysisMiamiUSA

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