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Nitric Oxide

  • Nariyuki Hayashi
  • Dalton W. Dietrich

Abstract

Recent data have implicated the importance of nitric oxide (NO) in the pathophysiology of traumatic brain injury (TEl) [2, 3, 4, 5]. After controlled cortical impact injury, levels of neuronal nitric oxide synthase (nNOS), mRNA, and protein increased by 2h after trauma [3]. Using a moderate F-P model, Wada and colleagues [4] reported the immediate but transient increase in constitutive nitric oxide synthase (cNOS) activity within the histopathologically injured cortical region.This increase in cNOS activity was followed by a sustained reduction in cNOS activity below control levels. Inducible NOS (iNOS) activity was also reported to increase at 7 days after TEl [5]

Keywords

Nitric Oxide Traumatic Brain Injury Therapeutic Hypothermia cNOS Activity Matic Brain Injury 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Chatzipanteli K, Wada K, Busto R, Dietrich WD (1999) Effects of moderate hypothermia on constitutive and inducible nitric oxide synthase activities after traumatic brain injury. J Neurochem 72:2047–2052PubMedCrossRefGoogle Scholar
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    Raghavendra Rao VL, Dogan A, Bowen K, Dempsey RJ (1999) Traumatic injury to rat brain upregulates neuronal nitric oxide synthase expression and L-[3H]nitroarginine binding. J Neurotrauma 16:865–877CrossRefGoogle Scholar
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    Wada K, Chatzipantelli K, Busto R, Kraydieh S, Dietrich WD (1998) Inducible nitric oxide synthase activation after traumatic brain injury. Neurosurgery 43:1427–1436PubMedGoogle Scholar

Copyright information

© Springer Japan 2004

Authors and Affiliations

  • Nariyuki Hayashi
    • 1
    • 2
  • Dalton W. Dietrich
    • 3
    • 4
  1. 1.Nihon University Emergency Medical CenterTokyoJapan
  2. 2.Department of Emergency and Critical Care MedicineNihon University School of MedicineTokyoJapan
  3. 3.Department of Neurological Surgery, Neurology and Cell Biology and AnatomyUniversity of Miami School of MedicineMiamiUSA
  4. 4.The Miami Project to Cure ParalysisMiamiUSA

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