Decrease of Vascular Permeability

  • Nariyuki Hayashi
  • Dalton W. Dietrich


Blood-brain barrier (BBB) dysfunction and cere-brovascular damage after neurotrauma are believed to participate in patterns of neuronal vulnerability [1,2,4,7,10,11]. Alteration in BBB permeability may contribute to the detrimental effects of traumatic injury through excitotoxic processes, as well as allowing abnormal passage of blood-borne exogeno us neurotran smitters into the central nervous system and influencing injury processes [9]. Experimental data have demonstrated that postinjury temperature modulations significantly influence vascular permeability. For example, although mode rate hypothermia after transient global ischemia attenuates the degree of postischemichor seradish peroxidase (HRP) extravasation compared to normothermia, hyperthermia aggravates permeability alterations [3]. In models of traumatic brain injury (TBI), the detrimental consequences of TBI on BBB damage have also been report ed to be reduced by posttraumatic hypothermia [6,8].


Traumatic Brain Injury Control Cortical Impact Transient Global Ischemia Systemic Hypothermia Plasma Protein Extravasation 
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Copyright information

© Springer Japan 2004

Authors and Affiliations

  • Nariyuki Hayashi
    • 1
    • 2
  • Dalton W. Dietrich
    • 3
    • 4
  1. 1.Nihon University Emergency Medical CenterTokyoJapan
  2. 2.Department of Emergency and Critical Care MedicineNihon University School of MedicineTokyoJapan
  3. 3.Department of Neurological Surgery, Neurology and Cell Biology and AnatomyUniversity of Miami School of MedicineMiamiUSA
  4. 4.The Miami Project to Cure ParalysisMiamiUSA

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