Abstract
Among the pathomechanisms involved with traumatic brain and spinal cord injury, reactive oxygen species and lipid peroxidation play an important role [3,4]. In a model of global cerebral ischemia, Baiping and colleagues [1] reported that moderate hypothermia (30°–32°C) attenuated lipid peroxidation. In a model of fluid-percussion brain injury, posttraumatic hypothermia (30°C) reduced the production of free radicals, as measured by the hydroxylation of salicylate by hydroxyl radicals to produce 2,5-dihydroxybenzoic acid, compared with normothermic trauma [2]. Interestingly, a significant correlation between the magnitude of glutamate release and the extent of hydroxyl radical production was demonstrated in that study, suggesting a link between the two responses. Posttraumatic hypothermia may therefore improve outcome by attenuating free radical formation and excitotoxicity. A current question is whether these relatively early posttraumatic events can be successfully targeted for treatment.
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© 2004 Springer Japan
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Hayashi, N., Dietrich, D.W. (2004). Free Radical Production. In: Brain Hypothermia Treatment. Springer, Tokyo. https://doi.org/10.1007/978-4-431-53953-7_14
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DOI: https://doi.org/10.1007/978-4-431-53953-7_14
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-67964-6
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