Free Radical Production

  • Nariyuki Hayashi
  • Dalton W. Dietrich


Among the pathomechanisms involved with traumatic brain and spinal cord injury, reactive oxygen species and lipid peroxidation play an important role [3,4]. In a model of global cerebral ischemia, Baiping and colleagues [1] reported that moderate hypothermia (30°–32°C) attenuated lipid peroxidation. In a model of fluid-percussion brain injury, posttraumatic hypothermia (30°C) reduced the production of free radicals, as measured by the hydroxylation of salicylate by hydroxyl radicals to produce 2,5-dihydroxybenzoic acid, compared with normothermic trauma [2]. Interestingly, a significant correlation between the magnitude of glutamate release and the extent of hydroxyl radical production was demonstrated in that study, suggesting a link between the two responses. Posttraumatic hypothermia may therefore improve outcome by attenuating free radical formation and excitotoxicity. A current question is whether these relatively early posttraumatic events can be successfully targeted for treatment.


Spinal Cord Injury Free Radical Production Free Radical Formation Global Cerebral Ischemia Moderate Hypothermia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Baiping L, Xiujuan T, Hongwei C, Qiming X, Quling G (1994) Effect of moderate hypothermia on lipid peroxidation in canine brain tissue after cardiac arrest and resuscitation. Stroke 25:147–152CrossRefGoogle Scholar
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    Globus MY-T, Alonso O, Dietrich WD, Busto R, Ginsberg MD (1995) Glutamate release and free radical production following brain injury: effects of posttraumatic hypothermia. J Neurotrauma 65:1704–1711Google Scholar
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    Hall ED, Andrus PK, Yonkers PA (1993) Brain hydroxyl radical generation in acute experimental head injury. J Neurochem 60:588–594PubMedCrossRefGoogle Scholar
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    Kontos HA, Povlishock JT (1986) Oxygen radicals in brain injury. Cent Nerv Syst Trauma 3:257–263PubMedGoogle Scholar

Copyright information

© Springer Japan 2004

Authors and Affiliations

  • Nariyuki Hayashi
    • 1
    • 2
  • Dalton W. Dietrich
    • 3
    • 4
  1. 1.Nihon University Emergency Medical CenterTokyoJapan
  2. 2.Department of Emergency and Critical Care MedicineNihon University School of MedicineTokyoJapan
  3. 3.Department of Neurological Surgery, Neurology and Cell Biology and AnatomyUniversity of Miami School of MedicineMiamiUSA
  4. 4.The Miami Project to Cure ParalysisMiamiUSA

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