Recent investigations have emphasized the importance of the rewarming phase in determining whether brain cooling is protective. Slow but not rapid rewarming provides the benefit in terms of histopathological outcome. In clinical studies, slow rewarming after a period of induced hypothermia is used routinely because of the potential detrimental effects of rebound intracranial hypertension when temperature increases rapidly [1,2,4]. In experimental studies, several reports recently emphasized the importance of slow rewarming in injury models [5,7]. For example, in a transient forebrain ischemia study, rapid rewarming failed to provide the neuroprotective effect of hypothermia that was observed with slow rewarming . In that study, rapid rewarming, after hypothermia resulted in poor recovery of mean arterial blood pressure and cortical blood flow. These investigators suggested that aggravated uncoupling between blood flow and metabolism with rapid rewarming might reduce its protection with hypothermia.
KeywordsTraumatic Brain Injury Axonal Injury Acute Brain Injury Transient Forebrain Ischemia Brain Cool