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Introduction

  • Nariyuki Hayashi
  • Dalton W. Dietrich

Abstract

The beneficial effects of mild to moderate hypothermia in experimental models of brain [4, 5, 6,9,15,20,26] and spinal cord injury [1,18,21,22,24,27] have been reported in many laboratories. Using models of diffuse as well as focal injury, brain and spinal cord cooling have been shown to protect against neuronal damage and improve behavioral outcome. Recently, posttraumatic hypothermia has also been reported to protect against axonal damage [14,16,19]. In addition, the blood-brain barrier consequences of cerebral ischemia and traumatic brain injury are attenuated by moderate hypothermia [8,12,23]. Taken together, these investigations, using different animal models and various morphological and functional endpoints, emphasize how remarkably effective hypothermia can be in protecting central nervous system tissue [2]. Importantly, these experimental findings of therapeutic hypothermia have been supported by clinical data where hypothermic protection has been demonstrated in patients after cardiac arrest and brain trauma [7,10,13,17,25].

Keywords

Traumatic Brain Injury Spinal Cord Injury Therapeutic Hypothermia Severe Traumatic Brain Injury Spinal Cord Ischemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Allen BT, Davis CG, Osborne D, Karl I (1994) Spinal cord ischemia and reperfusion metabolism: the effect of hypothermia. J Vase Surg 19:332–339CrossRefGoogle Scholar
  2. 2.
    Barone FC, Feuerstein GZ, White RF (1997) Brain cooling during transient focal ischemia provides complete neuroprotection. Neurosci Biobehav Rev 21:31–44PubMedCrossRefGoogle Scholar
  3. 3.
    Bernard SA, Gray TW, Buist MD, Jones BM, Silvester W, Gutteridge G, Smith K (2002) Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med 346:557–563PubMedCrossRefGoogle Scholar
  4. 4.
    Bramlett H, Green EJ, Dietrich WD, Busto R, Globus MYT, Ginsberg MD (1995) Post-traumatic brain hypothermia provides protection from sensorimotor and cognitive behavioral deficits. J Neurotrauma 12:289–298PubMedCrossRefGoogle Scholar
  5. 5.
    Busto R, Dietrich WD, Globus MY-T, Valdes I, Scheinberg P, Ginsberg MD (1987) Small differences in intraischemic brain temperature critically determine the extent of ischemic neuronal injury. J Cereb Blood Flow Metab 7:729–738PubMedCrossRefGoogle Scholar
  6. 6.
    Clark RSB, Robertson CL, Dixon CE, Alexander HL, Graham SH, Safar PJ, Kochanek PM (1999) Effect of hypothermia after severe traumatic brain injury with secondary hypoxemia in rats. J Neurotrauma 15:864 (Abstract)Google Scholar
  7. 7.
    Clifton GL (1995) Systemic hypothermia in treatment of severe brain injury: a review and update. J Neurotrauma 12:923–927PubMedCrossRefGoogle Scholar
  8. 8.
    Dietrich WD, Busto R, Halley M, Valdes I (1990) The importance of brain temperature in alterations of the blood-brain barrier following cerebral ischemia. J Neuropathol Exp Neurol 49:486–497PubMedCrossRefGoogle Scholar
  9. 9.
    Dietrich WD, Alonso O, Busto R, Globus MY-T, Ginsberg MD (1994) Post-traumatic brain hypothermia reduces histopathological damage following contusive brain injury in the rat. Acta Neuropathol 87:250–258PubMedCrossRefGoogle Scholar
  10. 10.
    Hayashi N, Hirayama T, Utagawa A (1994) The cerebral thermo-pooling and hypothermia treatment of critical head injury patients. In: Nagai H (ed) Intracranial pres sure IX. Springer, Berlin Heidelberg New York Tokyo, pp 589–599Google Scholar
  11. 11.
    Holzer M, Cerchiari E, Martens P, Roine R, Strez F (2002) Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med 346:549–555CrossRefGoogle Scholar
  12. 12.
    Jiang J-Y, Lyeth BG, Kapasi MZ, Jenkins LW, Povlishock JT (1992) Moderate hypothermia reduces blood-brain barrier disruption following traumatic brain injury in the rat. Acta Neuropathol 84:495–500PubMedCrossRefGoogle Scholar
  13. 13.
    Jiang J-Y, Yu M-K, Zhu C (2000) Effect of long-term hypothermia therapy in patients with severe traumatic brain injury: I-year follow-up review of 87 cases. J Neurosurg 93:546–549PubMedCrossRefGoogle Scholar
  14. 14.
    Koizumi H, Povlishock IT (1998) Posttraumatic hypothermia in the treatment of axonal damage in an animal model of traumatic axonal injury. J Neurosurg 89:303–309PubMedCrossRefGoogle Scholar
  15. 15.
    Lyeth BG, Jiang J-Y, Shanliang L (1993) Behavioral protection by moderate hypothermia initiated after experimental traumatic brain injury. J Neurotrauma 10:57–64PubMedCrossRefGoogle Scholar
  16. 16.
    Marion DW, White MJ (1996) Treatment of experimental brain injury with moderate hypothermia and 21-aminosteroids. J Neurotrauma 13:139–147PubMedCrossRefGoogle Scholar
  17. 17.
    Marion DW, Penrod LE, Kelsey SF, Obrist WD, Kochanek PM, Palmer AM, Wisniewki SR, DeKosky ST (1997) Treatment of traumatic brain injury with moderate hypothermia. N Eng J Med 336:540–546CrossRefGoogle Scholar
  18. 18.
    Marsala M, Vanicky I, Yaksh TL (1994) Effect of graded hypothermia (27° to 34°C) on behavioral function, histopathology, and spinal cord blood flow after spinal ischemia in rat. Stroke 25:2038–2046PubMedCrossRefGoogle Scholar
  19. 19.
    Maxwell WL, Donnelly S, Sun X, Fenton T, Pure N, Graham DI (1999) Axonal cytoskeletal response to nondisruptive axonal injury and the short-term effects of posttraumatic hypothermia. J Neurotrauma 16:1225–1234PubMedCrossRefGoogle Scholar
  20. 20.
    Palmer AM, Marion DW, Botsceller ML, Redd EE (1993) Therapeutic hypothermia is cytoprotective without attenuating the traumatic brain injury-induced elevations in interstitial concentrations of aspartate and glutamate. J Neurotrauma 10:363–372PubMedCrossRefGoogle Scholar
  21. 21.
    Robertson CS, Folz R, Grossman RG, Goodman JC (1986) Protection against experimental ischemic spinal cord injury. J Neurosurg 64:633–642PubMedCrossRefGoogle Scholar
  22. 22.
    Rokkas CK, Cronin CS, Nitta T, Helfrich LR, Lobner DC, Choi DW, Kouchoukos NT (1995) Profound systemic hypothermia inhibits the release of neurotransmitter amino acids in spinal cord ischemia. J Thorac Cardiovasc Surg 110:27–35PubMedCrossRefGoogle Scholar
  23. 23.
    Smith SL, Hall ED (1996) Mild pre-and posttraumatic hypothermia attenuates blood-brain barrier damage following controlled cortical impact injury in the rat. J Neurotrauma 13:1–9PubMedCrossRefGoogle Scholar
  24. 24.
    Vacanti FX, Ames A (1984) Mild hypothermia and Mg++ protect against irreversible damage during CNS ischemia. Stroke 15:695–698PubMedCrossRefGoogle Scholar
  25. 25.
    Wakamatsu H, Matsumoto M, Nakakimura K, Sakabe T (1999) The effects of moderate hypothermia and intrathecal tetracaine on glutamate concentrations of intrathecal dialysate and neurologic and histopathologic outcome in transient spinal cord ischemia in rabbits. Anesth Analg 88:56–62PubMedGoogle Scholar
  26. 26.
    Yamamoto M, Marmarou CR, Stiefel MF, Beaumont A, Marmarou A (1999) Neuroprotective effect of hypothermia on neuronal injury in diffuse traumatic brain injury coupled with hypoxia and hypotension. J Neurotrauma 16:487–500PubMedCrossRefGoogle Scholar
  27. 27.
    Yu CG, Marcillo AE, Dietrich WD, Fairbanks CA, Wilcox GL, Yezierski RP (1999) Beneficial effects of hypothermia and/or agmatine on locomotor outcome following contusion spinal cord injury. Soc Neurosci Abstr 29:268Google Scholar

Copyright information

© Springer Japan 2004

Authors and Affiliations

  • Nariyuki Hayashi
    • 1
    • 2
  • Dalton W. Dietrich
    • 3
    • 4
  1. 1.Nihon University Emergency Medical CenterTokyoJapan
  2. 2.Department of Emergency and Critical Care MedicineNihon University School of MedicineTokyoJapan
  3. 3.Department of Neurological Surgery, Neurology and Cell Biology and AnatomyUniversity of Miami School of MedicineMiamiUSA
  4. 4.The Miami Project to Cure ParalysisMiamiUSA

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