Depression is one of the most prevalent and costly brain diseases. Available antidepressant drugs are safe and effective, but less than half of all patients attain complete remission with single antidepressant and others exhibit partial, refractory or intolerant responses to treatment. Therefore, these findings emphasize the need to discover new antidepressants. The neurogenic hypothesis postulates that a reduced production of new neurons in the adult hippocampus is involved in pathogenesis of depression and an enhancement of hippocampal neurogenesis is one of mechanisms for the successful antidepressant treatment. This article examines this hypothesis with experimental and clinical data.


Hippocampal Volume cAMP Response Element Binding Hippocampal Neurogenesis Chronic Unpredictable Stress Newborn Neuron 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work was supported in part by Grant-in-aid No. 18591269 for Scientific Research from the Ministry of Education, Science and Culture, Japan.


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© Springer 2011

Authors and Affiliations

  1. 1.Department of PsychiatryHokkaido University Graduate School of MedicineKita-kuJapan
  2. 2.Division of Molecular Psychiatry, Abraham Ribicoff Research Facilities, Connecticut Mental Health CenterYale University School of MedicineNew HavenUSA

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