Stress Disorders

  • Muriel Koehl
  • Michel Le Moal
  • Djoher Nora Abrous


Recent years have produced rapid and enormous growth in our understanding of the mechanisms regulating adult neurogenesis. Emerging fields of research now aim at clarifying the relationships between neurogenesis and diseases. This paper deals with neurogenesis and stress-related disorders. After a brief overview of the stress response, we first provide a comprehensive analysis of the literature on the effects of stress on neurogenesis and the potential mechanisms underlying these effects. This analysis clearly indicates that, whatever the nature, intensity and duration of the stressor, stress decreases cell proliferation. Comparing different stress paradigms further indicates that these effects are transient when stress is performed during adulthood, while it has a much greater and longer lasting impact when applied during developmental periods. When uncontrolled or repeated, stressors are risk factors for physiological and psychiatric disorders such as depression, pathological aging, drug misuse, anxiety and post-traumatic stress disorder. Studies linking these pathologies and neurogenesis constitute an important field of research, but advances are hampered by the lack of adequate animal models. The challenge for future research will certainly be to develop these animal models in order to envision therapeutic strategies aimed at stimulating plasticity in the stressed brain and preventing the alteration of affective and cognitive function that may appear in some individuals.


Dentate Gyrus Adult Neurogenesis Hippocampal Neurogenesis Prenatal Stress Maternal Separation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer 2011

Authors and Affiliations

  • Muriel Koehl
    • 1
  • Michel Le Moal
    • 1
  • Djoher Nora Abrous
    • 1
  1. 1.Inserm U862, Institut F. MagendieUniversity of Bordeaux 2Bordeaux CedexFrance

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