Adult Neurogenesis in Epilepsy


Epilepsy is a devastating illness affecting about 50 million people worldwide that disturbs multiple aspects of brain integrity and function. Epileptic seizures may not only lead to degeneration of affected areas but also strongly induces the birth of new neurons generated by adult neural stem cells (NSCs) in the two neurogenic areas of the adult brain, the hippocampal dentate gyrus (DG) and the subventricular zone (SVZ) lining the lateral ventricles. In this chapter, we focus on mesial temporal lobe epilepsy (mTLE), which is the most common and often intractable form of acquired epilepsy. We will review and discuss recent data derived from rodent models of mTLE and human samples analyzing the effects of epileptic activity on NSC activity, neuronal differentiation and integration, and the potential role that newborn neurons may play in the epileptic disease process.


Granule Cell Status Epilepticus Dentate Gyrus Mossy Fiber Granule Cell Layer 
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© Springer 2011

Authors and Affiliations

  1. 1.Department of Biology, Institute of Cell BiologySwiss Federal Institute of Technology (ETH) ZürichZurichSwitzerland
  2. 2.Department of NeurologyUniversity of MichiganAnn ArborUSA

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