Adult Neurogenesis in Parkinson’s Disease
Parkinson’s disease (PD) is one of the most common neurodegenerative diseases. Its pathogenesis is based on diminution of neurons in the substantia nigra (SN) that under normal conditions acts as the source of dopamine in the nigrostriatal circuit. Although the etiology of PD remains poorly understood, recent understanding of the mechanisms of neurogenesis may reveal insights into the pathogenesis of PD and provide useful tools to treat PD. This review will focus on adult neurogenesis in SN, subventricular zone, striatum and olfactory bulb of PD and PD models. We also focus on adult neurogenesis in genetic PD models. The enhancement of progenitor cells may represent a potential new source of cells for replacement therapy in PD. In this review, possible treatments to enhance neurogenesis in PD models are also described.
KeywordsSubstantia Nigra Olfactory Bulb Adult Neurogenesis Neural Precursor Cell Newborn Neuron
This study was supported by the Program for Promotion of Fundamental Studies in Health Sciences of the National Institute of Biomedical Innovation (NIBIO).
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