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Neurogenesis in the Adult Brain II pp 23–36Cite as

Adult Neurogenesis in Parkinson’s Disease

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Abstract

Parkinson’s disease (PD) is one of the most common neurodegenerative diseases. Its pathogenesis is based on diminution of neurons in the substantia nigra (SN) that under normal conditions acts as the source of dopamine in the nigrostriatal circuit. Although the etiology of PD remains poorly understood, recent understanding of the mechanisms of neurogenesis may reveal insights into the pathogenesis of PD and provide useful tools to treat PD. This review will focus on adult neurogenesis in SN, subventricular zone, striatum and olfactory bulb of PD and PD models. We also focus on adult neurogenesis in genetic PD models. The enhancement of progenitor cells may represent a potential new source of cells for replacement therapy in PD. In this review, possible treatments to enhance neurogenesis in PD models are also described.

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Acknowledgment

This study was supported by the Program for Promotion of Fundamental Studies in Health Sciences of the National Institute of Biomedical Innovation (NIBIO).

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Authors and Affiliations

  1. Department of Neurology, School of Medicine, Kitasato University, 1-15-1 Kitasato, Sagamihara, Kanagawa, 228-8555, Japan

    Hideki Mochizuki

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  1. Hideki Mochizuki
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Correspondence to Hideki Mochizuki .

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Editors and Affiliations

  1. Department of Histology and Neuroanatomy, Tokyo Medical University, Tokyo, 160-8402, Japan

    Tatsunori Seki Ph.D. (Professor) (Professor)

  2. Department of Developmental and Regenerative Biology, Institute of Molecular Medicine Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan

    Kazunobu Sawamoto Ph.D. (Professor) (Professor)

  3. Department of Neurology, University of Michigan, 109 Zina Pitcher Place 5021 BSRB, Ann Arbor, MI, 48109, USA

    Jack M. Parent M.D. (Associate Professor) (Associate Professor)

  4. Department of Neurosurgery, University of California, San Francisco, San Francisco, CA, 94143, USA

    Arturo Alvarez-Buylla Ph.D. (Professor) (Professor)

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Mochizuki, H. (2011). Adult Neurogenesis in Parkinson’s Disease. In: Seki, T., Sawamoto, K., Parent, J.M., Alvarez-Buylla, A. (eds) Neurogenesis in the Adult Brain II. Springer, Tokyo. https://doi.org/10.1007/978-4-431-53945-2_2

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