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Neurogenesis in Monkey and Human Adult Brain

  • Andréanne Bédard
  • Patrick J. Bernier
  • André Parent

Abstract

This paper summarizes the results of our studies on adult neurogenesis in some key structures of the monkey and human brain. These results stem from multiple immunocytochemical investigations undertaken with antigens raised against various molecular markers of neurogenesis, either alone or in combination with the DNA synthesis indicator bromodeoxyuridine (BrdU). This approach has allowed us to provide the first detailed picture of the organization of the rostral migratory stream (RMS) in adult squirrel monkeys. Furthermore, studies on human postmortem tissue have revealed, for the first time, that the adult human olfactory bulb is the recipient of neuroblasts that migrate along the RMS and progressively develop a GABAergic or dopaminergic phenotype. A new migratory stream that provides newborn neurons to the amygdala and adjacent piriform cortex has also been visualized in squirrel monkeys. Finally, the striatum of normal adult squirrel monkeys was found to harbor newly generated cells that eventually become projection neurons. The recruitment of such striatal neurons was markedly increased in the presence of brain-derived neurotrophic factor (BDNF), a finding that raises hope for the development of novel therapeutic approaches for the treatment of ­certain neurodegenerative diseases.

Keywords

Olfactory Bulb Dentate Gyrus Squirrel Monkey Adult Neurogenesis Temporal Stream 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

ac

Anterior commissure

AdBDNF

Adenoviral vector overexpressing BDNF

AMY

Amygdala

BDNF

Brain-derived neurotrophic factor

BrdU

Bromodeoxyuridine

c

Caudal (posterior)

CB

Calbindin

cc

Corpus callosum

CD

Caudate nucleus

ChAT

Choline acetyltransferase

CMV

Cytomegalovirus

CR

Calretinin

CT

Cortex

DARPP-32

Dopamine- and cAMP-regulated phosphoprotein of 32 kDa

DCX

Doublecortin

EPL

External plexiform layer

FL

Fiber layer

GAD

Glutamic acid decarboxylase

GAD65/67

GAD 65 and 67 isoforms

GCL

Granular cell layer

GFAP

Glial fibrillary acidic protein

GL

Glomerular layer

HIPPO

Hippocampus

HL

Horizontal limb

ic

Internal capsule

Ki-67

Cell cycle-associated protein

LV

Lateral ventricle

MAP-2

Microtubule-associated protein 2

MCL

Mitral cell layer

NA

Nucleus accumbens

NeuN

Neuronal nuclear protein

NeuroD

Neuronal determination and differentiation transcription factor

OB

Olfactory bulb

ONL

Olfactory nerve layer

OT

Olfactory tubercle

PCNA

Proliferating cell nuclear antigen

PIRI

Piriform cortex

PL

Posterior limb

PSA-NCAM

Polysialylated neural cell adhesion

PUT

Putamen

PV

Parvalbumin

r

Rostral (anterior)

RMS

Rostral migratory stream

SS

Somatostatin

SVZ

Subventricular zone

SVZa

Anterior part of SVZ

TH

Tyrosine hydroxylase

tLV

Temporal horn of LV

TS

Temporal migratory stream

TUC-4

Collapsin response mediator protein-4

TuJ1

β-Tubulin-III

VL

Vertical limb

Notes

Acknowledgments

This study was supported by grant MT-8756 of the Canadian Institutes for Health Research (CIHR) to A. Parent. A. Bédard and P.J. Bernier were recipients of CIHR Studentships.

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Copyright information

© Springer 2011

Authors and Affiliations

  • Andréanne Bédard
    • 1
  • Patrick J. Bernier
    • 1
  • André Parent
    • 1
  1. 1.Centre de Recherche Université Laval Robert-GiffardBeauportCanada

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