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Molecular recognition by Ig-like receptors, KIRs and FcγRs

  • Conference paper
Activating and Inhibitory Immunoglobulin-like Receptors

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Summary

Structural studies by us and other groups have shown that Killer cell Ig-like receptors (KIRs) and Fcγ receptors (FcγR) have a similar, unique topology (intermediate between I set and C2 set). In order to gain further insight into molecular recognition by these receptors, we have used surface plasmon resonance (SPR) to analyze the kinetic and thermodynamic properties of their interactions with their natural ligands.

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Author information

Authors and Affiliations

  1. Structural Biology Center, National Institute of Genetics, Mishima, Shizuoka, 411-8540, Japan

    Katsumi Maenaka

  2. Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford, OX3 7BN, UK

    David I. Stuart & E. Yvonne Jones

  3. Sir William Dunn School of Pathology, University of Oxford, Oxford, OX1 3RE, UK

    P. Anton van der Merwe

  4. Max-Planck-Institut für Biochemie, Abteilung Strukturforschung, Am Klopferspitz 18a, D-82152, Martinsried, Germany

    Peter Sondermann

Authors
  1. Katsumi Maenaka
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  2. P. Anton van der Merwe
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  3. David I. Stuart
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  4. Peter Sondermann
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  5. E. Yvonne Jones
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Editor information

Editors and Affiliations

  1. Howard Hughes Medical Institute, University of Alabama at Birmingham, 378 Wallace Tumor Institute UAB Station, Birmingham, Alabama, 35294, USA

    Max D. Cooper M.D.

  2. Department of Experimental Immunology, Institute of Development, Aging and Cancer Tohoku University, Seiryo 4-1, Sendai, 980-8575, Japan

    Toshiyuki Takai Ph.D.

  3. Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York, 10021-6399, USA

    Jeffrey V. Ravetch M.D., Ph.D.

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© 2001 Springer Japan

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Maenaka, K., van der Merwe, P.A., Stuart, D.I., Sondermann, P., Jones, E.Y. (2001). Molecular recognition by Ig-like receptors, KIRs and FcγRs. In: Cooper, M.D., Takai, T., Ravetch, J.V. (eds) Activating and Inhibitory Immunoglobulin-like Receptors. Springer, Tokyo. https://doi.org/10.1007/978-4-431-53940-7_6

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  • DOI: https://doi.org/10.1007/978-4-431-53940-7_6

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-67959-2

  • Online ISBN: 978-4-431-53940-7

  • eBook Packages: Springer Book Archive

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