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Regulated expression of non-polymorphic gp49 molecules on mouse natural killer cells

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Activating and Inhibitory Immunoglobulin-like Receptors

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Summary

Murine natural killer (NK) cells express inhibitory receptors belonging to the C-type lectin-like (Ly-49, CD94/NKG2) and Ig-superfamily related (gp49) receptors. The murine gp49B receptor displays structural homology with human killer inhibitory receptors (KIR) and other Ig-like receptors. By contrast to most of these receptors, gp49 molecules are not expressed by resting NK cells but are expressed when NK cells are activated in vitro. Importantly, gp49 molecules are also upregulated in the context of murine cytomegalovirus infection. Furthermore, the gp49 molecules do not appear to display allelic polymorphism, suggesting a unique functional role for gp49 molecules in regulating NK cells long after initial stimuli.

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Abbreviations

NK:

natural killer

KIR:

killer inhibitory receptor

MCMV:

murine cytomegalovirus

ITIM:

immunoreceptor tyrosine based inhibitory motif

mAb:

monoclonal antibody

LAK:

IL-2-activated NK cell

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Author information

Authors and Affiliations

  1. Howard Hughes Medical Institute, Division of Rheumatology, Departments of Medicine and of Pathology and Immunology, Washington University School of Medicine, Box 8045, St. Louis, MO, 63110, USA

    Lawrence L. Wang & Wayne M. Yokoyama

Authors
  1. Lawrence L. Wang
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  2. Wayne M. Yokoyama
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Editor information

Editors and Affiliations

  1. Howard Hughes Medical Institute, University of Alabama at Birmingham, 378 Wallace Tumor Institute UAB Station, Birmingham, Alabama, 35294, USA

    Max D. Cooper M.D.

  2. Department of Experimental Immunology, Institute of Development, Aging and Cancer Tohoku University, Seiryo 4-1, Sendai, 980-8575, Japan

    Toshiyuki Takai Ph.D.

  3. Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York, 10021-6399, USA

    Jeffrey V. Ravetch M.D., Ph.D.

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© 2001 Springer Japan

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Wang, L.L., Yokoyama, W.M. (2001). Regulated expression of non-polymorphic gp49 molecules on mouse natural killer cells. In: Cooper, M.D., Takai, T., Ravetch, J.V. (eds) Activating and Inhibitory Immunoglobulin-like Receptors. Springer, Tokyo. https://doi.org/10.1007/978-4-431-53940-7_4

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  • DOI: https://doi.org/10.1007/978-4-431-53940-7_4

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-67959-2

  • Online ISBN: 978-4-431-53940-7

  • eBook Packages: Springer Book Archive

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